Dialysis combination and microdialysis probe and insertion device

• US 5,741,284 A
• Filed: 07/31/1996
• Issued: 04/21/1998
• Est. Priority Date: 02/04/1994
• Status: Expired due to Term

• Current Assignee: Cma/Microdialysis Holding AB
• Original Assignee: Cma/Microdialysis Holding AB
• Inventors: Karlsson, Hans
• Primary Examiner(s): Rimell, Sam
• Assistant Examiner(s): Yeh, Luke
• Application Number:
  US08/682,745
• Time in Patent Office: 629 Days
• Field of Search: 604/160, 604/158, 604/161, 604/171, 604/177, 604/167, 604/27, 604/29
• US Class Current: 604/160
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 2010/008 Interstitial fluid
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61M 25/065 Guide needles

Abstract

A dialysis probe combination with a microdialysis probe (1) which can be inserted into tissue with the aid of an insertion device that includes a canula tube (9). In order to be able to remove the canula tube (9) after insertion, the tube is provided with a slot along the whole of its length, this slot preferably including an angle of about 65° in the radial direction. During insertion, the probe is held within the canula tube by virtue of the major part of the probe being larger than the slot. However, the proximal portion of the probe includes a flattened part which is able to pass through the slot, and the canula tube can be drawn past the flattened part by lifting this part, while leaving the probe in the tissue.

Claims

1. In a dialysis probe combination comprising a microdialysis probe which includes a semi-permeable membrane located and supported between two tubular members, with an inner tube which is provided with an opening at its distal end, and an outer mantle which includes the membrane, wherein the inner tube and the space defined between the inner tube and the outer mantle are each connected to a respective connecting pipe at the proximal end of the probe, and an insertion device which includes a removable cannula tube which is pointed at its distal end and which functions to stiffen the probe, the improvement wherein the cannula tube has a slot which extends along the full length of the cannula tube, and includes at its proximal end centrally opposite the slot a slot-exposing gripping element which is provided with at least one handle means which projects laterally outwards;

the outer mantle and the two tubular members are slidably accommodated within the cannula tube wherein at least the tubular members are held generally firm against lateral movement by virtue of their fit in the cannula tube;

a proximal end of the probe having at least one narrow part which fits in the slot, thereby enabling the cannula with the microdialysis probe inserted therein to be inserted through the skin and into the underlying tissue, wherein after insertion the narrowed probe part can be withdrawn through the slot in the cannula tube at the proximal end of said slot when the probe is located outside the skin, whereafter the complete cannula tube can be withdrawn with the slot passing beyond the stationary narrow part of the probe.

2. A dialysis probe combination according to claim 1, wherein attached to the proximal end of the probe is a gripping element which can be brought to a position opposite the slot in the cannula tube so as to bring the narrow part into the slot and so as to hold the probe firmly as the cannula tube is withdrawn past the probe.

3. A microdialysis probe comprising:

a semi-permeable membrane located between two tubular members having an inner tube which is provided with an opening at its distal end, and an outer mantle which includes the membrane, wherein the inner tube and an space defined between the inner tube and the outer mantle are each connected to a respective connecting pipe at the proximal end of a probe, and the probe has close to its proximal end at least one flattened part which narrows at sides thereof.

4. A probe according to claim 3, wherein a single-directional flat handle, which coincides essentially to a plane of said flattened part is attached to said probe proximate said flattened part.

5. An insertion device for inserting a tubular microdialysis probe into tissue, comprising:

a cannula tube which has a point at its distal end;

an axial slot which extends along the full length of the cannula tube, wherein the slot has a radial angle of approximately 65°

; and

a handle attached to a proximal end of the cannula tube, said handle comprising two adjacent walls that are affixed to the proximal end on opposite sides of the slot, each of said walls having a surface which is parallel to and faces a corresponding said surface of the other of said walls, said facing surfaces having a zone therebetween in the radial extension of the axial slot which is wider than the slot, each of said walls having affixed thereto a finger-grip wing which extends outwardly at a right angle.

6. An insertion device for inserting a tubular microdialysis probe into tissue, comprising:

a cannula tube which has a circumferential wall of even thickness and a point at its distal end;

an axial slot which extends along the full length of the cannula tube and which has longitudinal edges which define the circumferential extent of said wall of even thickness, wherein the slot has a radial angle of less than 180°

; and

a handle attached to a proximal end of the cannula tube, said handle having two parallel walls, each with a surface that faces a corresponding said surface on the other of said two parallel walls, said two parallel walls being affixed to the proximal end on opposite sides of the slot and having a zone between their facing surfaces in the radial extension of the axial slot which is wider than the slot, each of said two parallel walls having affixed thereto a finger-grip wing which extends outwardly at a right angle.