Artificial pancreatic perfusion device
First Claim
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1. An artifical pancreatic perfusion device, comprising:
- a. a hollow fiber having a porosity ranging from about 25 Kd to about 200 Kd;
said hollow fiber having a first end adapted to be connected to a blood vessel for receiving blood and a second end adapted to be connected to a blood vessel for returning blood;
b. islets of Langerhans surrounding said hollow fiber, wherein the fiber provides for a directly continuous blood flow between said receiving blood vessel and said returning blood vessel; and
c. a housing for said hollow fiber and islets, comprised in whole or in part by a semipermeable membrane;
said housing having a pore size small enough to offer protection to the islets and host from immune reactive substances.
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Abstract
An artifical pancreatic perfusion device comprising a hollow fiber having a porosity ranging from about 25 Kd to about 200 Kd. The hollow fiber has one end connected to a blood vessel for receiving blood and a second end connected to a blood vessel for returning said blood. Islets of Langerhans surround the hollow fiber. The hollow fiber and islets are surrounded by a housing comprising a semipermeable membrane having a pore size small enough to offer protection to the islets and host from immune reactive substances. Further disclosed is a method for providing and regulating insulin to insulin deficient individuals.
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Citations
21 Claims
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1. An artifical pancreatic perfusion device, comprising:
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a. a hollow fiber having a porosity ranging from about 25 Kd to about 200 Kd;
said hollow fiber having a first end adapted to be connected to a blood vessel for receiving blood and a second end adapted to be connected to a blood vessel for returning blood;b. islets of Langerhans surrounding said hollow fiber, wherein the fiber provides for a directly continuous blood flow between said receiving blood vessel and said returning blood vessel; and c. a housing for said hollow fiber and islets, comprised in whole or in part by a semipermeable membrane;
said housing having a pore size small enough to offer protection to the islets and host from immune reactive substances. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification