Biodegradable controlled release amylaceous material matrix

• US 5,741,521 A
• Filed: 05/30/1995
• Issued: 04/21/1998
• Est. Priority Date: 09/15/1989
• Status: Expired due to Term

• Current Assignee: GF Australia Pty Ltd. (Hong Leong Company (Malaysia) Bhd.), Incitec Fertilizers Limited, Penford Australia Limited (Ingredion Incorporated)
• Original Assignee: Goodman Fielder Limited (BPC1 Pty Limited), Incitec Ltd. (Orica Limited)
• Inventors: Anderson, Thomas Peter, Ahmetagic, Mirsad Ahmet, Knight, Adrian Timothy
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US08/454,093
• Time in Patent Office: 1,057 Days
• Field of Search: 424/486, 424/488, 424/487, 424/499, 424/501, 424/409, 71/64.01, 71/64.03, 71/64.07, 71/DIG. 1
• US Class Current: 424/488
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/12 Powders or granules A01N25/26 takes precedence
• CPC Class Codes: A01N 47/24 containing the groups , or; Thio analogues thereof
• CPC Class Codes: A01N 57/12 containing acyclic or cycloaliphatic radicals
• CPC Class Codes: A01N 57/16 containing heterocyclic radicals
• CPC Class Codes: A01N 63/23 B. thuringiensis
• CPC Class Codes: C05G 5/40 Fertilisers incorporated into a matrix

Abstract

A biodegradable or digestible matrix is provided suitable for use as a controlled release of an agriculturally active agent such as insecticides, fungicides, fertilizers, plant growth regulants, etc. The matrix comprises an amylaceous material optionally in association with a synthetic polymer and is formed under elevated temperature and pressure.

Claims

1. A method for manufacture of a biodegradable matrix shape for use in connection with the controlled release delivery of an agriculturally active agent, said method comprising the steps of:

(a) providing a composition comprising an amylaceous material having an amylose content of at least 50% w/w and water, said water being present in an amount of from about 2 to about 30% w/w, said amylaceous material selected from the group consisting of amylose, waxy maize starch, wheat starch, tapioca starch, pea starch and combinations thereof,

(b) heating said composition to a temperature of no more than about 150°

C. at a pressure of no more than about 4000 psi to form a uniform hot melt from said composition without destructurising said amylaceous material within said composition, and

(c) forming said hot melt into a desired matrix shape,

incorporating said agriculturally active agent is incorporated in said composition in steps (a) or (b) or within said matrix shape produced in step (c),

optionally incorporating within said composition of steps (a) or (b) a filler in an amount of less than about 95% by weight and a plasticizer in an amount of up to about 20% by weight, and further optionally incorporating a synthetic polymer in an amount of up to about 90% by weight within said composition of steps (a) or (b) or within said matrix shape produced in step (c).

2. A method according to claim 1 wherein said active agent is incorporated into said matrix shape by admixing with said composition in step (a).

3. A method according to claim 1 wherein said active agent is admixed with said hot melt during step (b).

4. A method according to claim 1 wherein the hot melt is formed into said matrix shape by extrusion.

5. A method according to claim 4 wherein the temperature during extrusion is in the range of from 70°

-100°

C. and the pressure is from 200-500 psi.

6. A method according to claim 1 further comprising subjecting the hot melt to atmospheric or sub-atmospheric pressure immediately prior to or during step (b) to remove water from the hot melt prior to the formation of the matrix shape.

7. A method according to claim 6 further comprising the step of crosslinking the amylaceous material during or after step (b).

8. A method according to claim 1 wherein said amylaceous material is selected from the group consisting of amylaceous ethers, amylaceous esters, and combinations thereof, amylaceous alkyl succinates and starch molecules having synthetic polymeric branches grafted thereon.

9. A method according to claim 8 wherein the amylaceous ether is a hydroxyalkyl derivative or carboxyalkyl derivative.

10. A method according to claim 9 wherein the amylaceous ester is a saturated fatty acid derivative.

11. A method according to claim 9 wherein the amylaceous alkyl succinate is starch octenyl succinate.

12. A method according to claim 1 wherein the composition of step (a) comprises from about 2% to about 20% by weight of water.

13. A method according to claim 12 wherein the composition of step (a) comprises from about 5 to about 15% by weight of water.

14. A method according to claim 1 wherein said synthetic polymer is present in the composition in an amount of less than about 25% by weight.

15. A method according to claim 14 wherein the hot melt is formed into the desired shape by extrusion at a temperature of from 120°

-140°

C. and a pressure of from 100-1000 psi.

16. A method according to claim 15 wherein in step (b), the matrix shape is co-formed with at least one layer of a synthetic polymer.

17. A method according to claim 16 wherein the matrix shape is co-extruded with the synthetic polymer.

18. A method according to claim 15 wherein the matrix shape from step (b) is coated with a synthetic polymer by way of spraying or brushing.

19. A method according to claim 14 wherein said synthetic polymer is present in the composition in an amount of less than about 15% by weight.

20. A method according to claim 1 wherein the synthetic polymer is selected from the group consisting of low density polyethylene and high density polyethylene, a copolymer of ethylene vinyl acetate, a copolymer of ethylene acrylic acid, polyvinyl chloride, polystyrene, chlorinated polyethylene, a copolymer of ethylene propylene, a copolymer of acrylic acid, polyvinyl acetals, polyamines and urethanes.

21. A method according to claim 1 wherein the composition comprises a filler in an amount of less than about 70% by weight of said composition.

22. A method according to claim 21 wherein said filler is selected from the group consisting of metal salts, clays, carbonaceous material, dextrose, talcs, silicas and ammonium sulphate.

23. A method according to claim 22 wherein said filler is selected from the group consisting of calcium carbonate, calcium sulphate, sodium carbonate, sodium sulphate, barium sulphate, kaolin, bentonite and wood flour.

24. A method according to claim 1 wherein a filler is incorporated into said composition prior to or during step (b).

25. A method according to claim 1 wherein the composition of step (a) or step (b) includes a plasticizer selected from the group consisting of a mono- or polyfunctional alcohol, invert sugar, dioctyl phthalate, chlorinated hydrocarbons, vegetable oil, and combinations thereof.

26. A method according to claim 25 wherein said alcohol is selected from the group consisting of polyethylene glycol, acetyl glycol and glycerol.

27. A method according to claim 25 wherein said vegetable oil is soya bean oil.

28. A method according to claim 1 wherein said active agent is selected from the group consisting of acaricides, insecticides, nematicides, herbicides, fungicides, plant growth regulants, fertilizers, trace nutrients, biological control agents and combinations thereof.

29. A method according to claim 28 wherein said active agent is selected from the group consisting of chlorpyrifos, carbosulfan, carbofuran, phorate, diuron and Bacillus thuringiensis.

30. A method according to claim 1 wherein said active agent is blended with the matrix shape from step (c).

31. A method according to claim 30 wherein said active agent is incorporated into said matrix shape by immersion or infusion.

32. A method according to claim 30 further comprising the step of cooling or allowing the matrix shape to cool prior to incorporating said agent herewith.

33. A controlled release biodegradable composition comprising a matrix of an amylaceous material in combination with an agriculturally active agent, said matrix formed by

(a) providing a composition comprising an amylaceous material having an amylose content of at least 50% w/w and water, said water being present in an amount of from about 2 to about 30% w/w, said amylaceous material selected from the group consisting of amylose, waxy maize starch, wheat starch, tapioca starch, pea starch and combinations thereof,

(b) heating said composition to a temperature of no more than about 150°

C. at a pressure of no more than about 4000 psi to form a uniform hot melt from said composition without destructurising said amylaceous material, and

(c) forming said hot melt into said matrix,

and said agriculturally active agent subject to controlled release and selected from the group consisting of acaricides, insecticides, nematicides, herbicides, fungicides, plant growth regulants, fertilizers, trace nutrients, biological control agents and combinations thereof, said matrix optionally comprising up to about 90% by weight of a synthetic polymer, up to about 20% by weight of a plasticizer and up to about 95% by weight of a filler.

34. A controlled release biodegradable composition according to claim 33 comprising a matrix comprising less than about 15% by weight of a synthetic polymer.

35. A controlled release biodegradable composition according to claim 33 wherein the amylaceous material is selected from the group consisting of amylaceous ethers, amylaceous esters, and combinations thereof;

amylaceous alkyl succinates and starch molecules having a synthetic polymer grafted thereon.

36. A controlled release biodegradable composition according to claim 35 wherein the amylaceous ether is a hydroxyalkyl derivative or carboxyalkyl derivative.

37. A controlled release biodegradable composition according to claim 36 wherein said amylaceous ether is a hydroxyethyl, hydroxypropyl, hydroxybutyl or carboxymethyl derivative.

38. A controlled release biodegradable composition according to claim 35 wherein the amylaceous alkyl succinate is starch octenyl succinate.

39. A controlled release biodegradable composition according to claim 35 wherein the amylaceous ester is a saturated fatty acid derivative.

40. A controlled release biodegradable composition according to claim 35 wherein said amylaceous material is crosslinked.

41. A controlled release biodegradable composition according to claim 33 wherein the synthetic polymer is selected from the group consisting of low density polyethylene and high density polyethylene, ethylene vinyl acetate copolymers, ethylene acrylic acid copolymers, polyvinyl chlorides, polystyrenes, chlorinated polyethylenes, ethylene propylene copolymers, acrylic acid copolymers, polyvinyl acetals, polyamines and urethanes.

42. A controlled release biodegradable composition according to claim 33 wherein the matrix is coated with the synthetic polymer.

43. A controlled release biodegradable composition according to claim 33 wherein the active agent is selected from the group consisting of chlorpyrifos, carbosulfan, carbofuran, phorate, diuron and Bacillus thuringiensis.

44. A controlled release biodegradable composition according to claim 33 wherein the filler is selected from the group consisting of metal salts, clays, carbonaceous material, dextroses, talcs, silicas and ammonium sulphate in an amount of less than about 70% by weight.

45. A controlled release biodegradable composition according to claim 44 wherein said filler is selected from the group consisting of calcium carbonate, calcium sulphate, sodium carbonate, sodium sulphate, barium sulphate, kaolin, bentonite and wood flour.

46. A controlled release biodegradable composition according to claim 33 having a dermal LD₅₀ as measured on rabbits which is greater than the dermal LD₅₀ for said active agent as measured on rabbits.

47. A controlled release biodegradable composition as claimed in claim 33 which is adapted for application to a crop growing area.

48. A controlled release biodegradable composition according to claim 33 wherein said composition includes a plasticizer selected from the group consisting of a mono- or polyfunctional alcohol, invert sugar, dioctyl phthalate, chlorinated hydrocarbons, vegetable oil and combinations thereof.

49. A controlled release biodegradable composition according to claim 33 wherein said synthetic polymer is present in an amount of up to about 25% by weight.