Insulin delivery enhanced by coached breathing
First Claim
1. A method of enhancing the rate at which insulin migrates into a patient'"'"'s circulatory system, comprising:
- aerosolizing a formulation;
inhaling the aerosolized formulation into lungs of a patient and allowing particles of insulin to deposit on lung tissue;
inhaling maximally followed by exhaling the forced vital capacity of the lungs.
4 Assignments
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Accused Products
Abstract
The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient'"'"'s lungs and the rate at which the insulin is absorbed into the blood is increased by the use of an inhale-exhale breathing maneuver. Particles of insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The rate of absorption is enhanced by instructing the patient to inhale maximally and thereafter exhale maximally. This maneuver causes a spike in the rate at which insulin enters the circulatory system thereby increasing the rate at which glucose is removed from the circulatory system. The insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release. The sensor can also assist the patient in the inhale-exhale maneuver.
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Citations
20 Claims
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1. A method of enhancing the rate at which insulin migrates into a patient'"'"'s circulatory system, comprising:
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aerosolizing a formulation; inhaling the aerosolized formulation into lungs of a patient and allowing particles of insulin to deposit on lung tissue; inhaling maximally followed by exhaling the forced vital capacity of the lungs. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of coaching a patient to enhance the rate of delivery of insulin deposited in the lungs of the patient, comprising:
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administering insulin to the patient by inhalation; and instructing the patient to inhale maximally followed by exhaling maximally. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification