Method for processing real-time contrast enhanced ultrasonic images

• US 5,743,266 A
• Filed: 04/25/1995
• Issued: 04/28/1998
• Est. Priority Date: 04/25/1995
• Status: Expired due to Fees

• Current Assignee: Molecular Biosystems, Inc (Alliance Pharmaceutical Corporation)
• Original Assignee: Molecular Biosystems, Inc (Alliance Pharmaceutical Corporation)
• Inventors: Levene, Harold, Webster, Bob
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/428,723
• Time in Patent Office: 1,099 Days
• Field of Search: 128/660.01, 128/662.02, 128/660.07, 128/660.05, 128/654, 128/653.4
• US Class Current: 600/458
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment
• CPC Class Codes: G01S 7/52071 Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging

Abstract

The present invention is a novel method for producing real-time colorized, contrast enhanced images from a sequence of grey-scale video images obtained during diagnostic ultrasound. The particular colorizing scheme varies according to which information parameter is desired to be displayed in real-time. The information parameters used to colorize a segment of video images include: time-to-arrival, duration of brightening, and absolute brightening. Time-to-arrival colorization depicts the time that a given pixel achieves a given intensity threshold. Duration of brightening depicts the time that a given pixel'"'"'s intensity stays above a given threshold. Absolute brightening depicts various threshold values obtained by the region'"'"'s pixels.

Claims

1. A method of colorizing corresponding points in a region of interest of a subject in a series of grey-scale ultrasound images comprising:

a) commencement of grey scale imaging of the region of interest of the subject;

b) administration of contrast agent to the subject wherein the contrast agent perfuses to the region of interest;

c) for the first image to be colorized, colorize each corresponding point according to the results of a comparison between a parameter and the value of the reflected signal of the corresponding point; and

d) for each subsequent image in the series, colorizing each corresponding point according to the results of a comparison made between a parameter, the value of the reflected signal from the corresponding point in the image and a previous non-baseline value of the reflected signal of the corresponding point.

2. The method of claim 1 wherein the contrast agent is chosen from the group consisting of liquid emulsions, solids, encapsulated fluids, encapsulated biocompatible gases and combinations thereof.

3. The method of claim 2 wherein the contrast agent comprises a fluorinated gas or liquid.

4. The method of claim 1 wherein the imaging is performed two-dimensionally.

5. The method of claim 1 wherein the imaging is performed three-dimensionally.

6. The method of claim 1 wherein said parameter is the time of arrival of the contrast agent.

7. The method of claim 1 wherein said parameter is the instantaneous degree of brightening of the tissue as a result of the arrival of the contrast agent.

8. The method of claim 1 wherein said parameter is the integrated degree of brightening of the tissue as the result of the arrival of the contrast agent.

9. The method of claim 1 wherein said parameter is the duration of the brightening by the contrast agent as it remains in the tissue.

10. The method of claim 1 wherein each said corresponding point is a pixel.

11. A method of diagnosing tissue/organ condition comprising:

a) commencement of grey scale imaging to obtain at least one baseline image;

b) administration of contrast agent to the subject for the obtainance of non-baseline images;

c) processing of images by colorization in real-time, wherein the colorization is made to corresponding points in said images in accordance with a parameter and two values of the reflected signal at the corresponding points, wherein one said value is derived from the current image being processed and the other said value is selectable from the set of baseline and non-baseline images; and

d) analyzing the colorized images.

12. The method of claim 11 wherein contrast agent is chosen from the group consisting of liquid emulsions, solids, encapsulated fluids, encapsulated biocompatible gases and combinations thereof.

13. The method of claim 12 wherein the contrast agent comprises a fluorinated gas or liquid.

14. The method of claim 11 wherein the imaging is performed two-dimensionally.

15. The method of claim 11 wherein the imaging is performed three-dimensionally.

16. The method of claim 11 wherein said parameter is the time of arrival of the contrast agent.

17. The method of claim 11 wherein said parameter is the instantaneous degree of brightening of the tissue as a result of the arrival of the contrast agent.

18. The method of claim 11 wherein said parameter is the integrated degree of brightening of the tissue as the result of the arrival of the contrast agent.

19. The method of claim 11 wherein said parameter is the duration of the brightening by the contrast agent as it remains in the tissue.

20. The method of claim 11 wherein the tissue being diagnosed comprises the heart.

21. The method of claim 20 wherein the processing is performed at more than one point in the cardiac cycle.

22. The method of claims 20 or 21 wherein the colorization includes the left ventricle region.

23. The method of claims 20 or 21 wherein the colorization does not include the left ventricle region.

24. The method of claim 11 wherein the tissue being diagnosed comprises kidney.

25. The method of claim 11 wherein the tissue being diagnosed comprises the brain.

26. The method of claim 11 wherein the tissue being diagnosed comprises the liver.

27. The method of claim 11 wherein the tissue being diagnosed comprises the testes.

28. The method of claim 11 wherein the tissue being diagnosed comprises muscle tissue.

29. The method of claim 11 wherein the tissue being diagnosed comprises the blood flow within tissue/organ.

30. The method of claim 11 wherein the processing is performed at more than one point in the cardiac cycle.

31. The method of claim 11 wherein each said corresponding point is a pixel.

32. A method for producing a series of real-time colorized images of corresponding points in a region of interest, said images taken with an ultrasound diagnostic scanning apparatus or an ultrasound image processing apparatus wherein the apparatus processes the series of grey scale images according to a pre-determined parameter;

the steps of the method comprise;

(a) identifying a region of interest in the images for processing;

(b) for the first grey scale image in the series,

(i) determining the value of the reflected signal of the corresponding point;

(ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter and the value determined in step (b)(ii),

(c) for each subsequent grey scale image,

(i) determining the value of the reflected signal of the corresponding point in the current image;

(ii) colorizing the corresponding point based upon a comparison of the pre-determined parameter, the value of the reflected signal of the corresponding point in the current image and the value of the reflected signal of the corresponding point in a previous image, wherein such previous image is selectable from the set of baseline and non-baseline images.

33. The method of claim 32 wherein the method further comprises two-dimensional imaging.

34. The method of claim 32 wherein the method further comprises three-dimensional imaging.

35. The method of claim 32 wherein said parameter is the time of arrival of contrast agent.

36. The method of claim 32 wherein said parameter is the instantaneous degree of brightening of the region of interest as a result of the arrival of contrast agent.

37. The method of claim 32 wherein said parameter is the integrated degree of brightening of the region of interest as the result of the arrival of contrast agent.

38. The method of claim 32 wherein said parameter is the duration of brightening by the contrast agent as it remains in the region of interest.