Photolabile nucleoside protecting groups
First Claim
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1. A reactor system for synthesizing a plurality of polymer sequences on a substrate comprising:
- a flow cell;
a substrate mounted on said flow cell forming a cavity between said substrate and said flow cell;
a system for delivering selected monomer containing reaction fluids to said cavity;
a mask;
a translation stage for moving said mask or said substrate from a first relative location to a second relative location;
an energy source for directing energy through said mask, at selected regions of said substrate at selected times; and
an appropriately programmed digital computer for selectively directing a flow of reaction fluids into said cavity, selectively activating said translation stage and selectively illuminating said substrate so as to form a plurality of diverse, known polymer sequences on said substrate at predetermined locations.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
132 Citations
11 Claims
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1. A reactor system for synthesizing a plurality of polymer sequences on a substrate comprising:
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a flow cell; a substrate mounted on said flow cell forming a cavity between said substrate and said flow cell; a system for delivering selected monomer containing reaction fluids to said cavity; a mask; a translation stage for moving said mask or said substrate from a first relative location to a second relative location; an energy source for directing energy through said mask, at selected regions of said substrate at selected times; and an appropriately programmed digital computer for selectively directing a flow of reaction fluids into said cavity, selectively activating said translation stage and selectively illuminating said substrate so as to form a plurality of diverse, known polymer sequences on said substrate at predetermined locations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification