Method of magnetic resonance arteriography using contrast agents

• US 5,746,208 A
• Filed: 08/06/1996
• Issued: 05/05/1998
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/689,270
• Time in Patent Office: 637 Days
• Field of Search: 128/653.3, 128/653.4, 128/654, 128/655, 128/659, 324/307, 324/309, 424/9.3, 424/9.36
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Claims

1. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

administering a magnetic resonance contrast agent to the patient;

and

collecting image data which is representative of a substantial portion of a center of k-space while the patient suspends respiration and a concentration of the contrast agent in the artery is substantially higher than the concentration of contrast agent in adjacent veins and background tissue.

2. The method of claim 1 wherein the step of collecting image data includes collecting image data using a 3D gradient echo pulse sequence and the step of administering a magnetic resonance contrast agent includes administering the contrast agent to the patient by bolus injection.

3. The method of claim 1 wherein the step of administering the magnetic resonance contrast agent further includes administering the contrast agent to the patient, by intravenous infusion, during collection of the image data and at a rate of infusion which is sufficient to provide a concentration of the contrast agent in the artery which is substantially higher than a concentration of contrast agent in veins adjacent to the artery during collection of the image data.

4. The method of claim 1 further including:

collecting pre-scanning image data of the artery prior to administering a magnetic resonance contrast agent to the patient, and

generating final image data of the artery using the pre-scanning image data and the image data which is representative of at least a portion of a center of k-space.

5. The method of claim 1 wherein the step of collecting image data includes collecting a portion of the image data which is representative of a center of k-space while the concentration of the contrast agent in the artery is substantially a maximum relative to adjacent veins and background tissue.

6. The method of claim 5 wherein the step of collecting image data further includes collecting the substantial portion of the image data which is representative of the center of k-space while a flip angle is between about 20°

0 to about 90°

, TR≦

30 milliseconds and TE≦

7 milliseconds.

7. The method of claim 5 wherein the step of administering the magnetic resonance contrast agent further includes administering the contrast agent to the patient substantially throughout the collection of the image data.

8. The method of claim 5 wherein the step of collecting the image data which is representative of the center of k-space further includes collecting at least a portion of the data after a signal intensity from a region of interest increases by more than about 100%.

9. The method of claim 5 wherein the step of collecting image data further includes collecting data which is representative of the center of k-space while the concentration of contrast agent in the artery is about a maximum and while a flip angle is between about 20°

to about 90°

.

10. The method of claim 1 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data while a field of view is greater than about 30 centimeters.

11. The method of claim 1 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data while a slice thickness is less than 5 millimeters.

12. The method of claim 1 wherein the step of collecting image data which is representative of the center of k-space includes using a body coil.

13. The method of claim 12 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data using a coronally oriented imaging volume.

14. A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the method comprising,

administering magnetic resonance contrast agent to the patient;

and

collecting image data which is representative of a center of k-space while the patient suspends respiration and while a concentration of the contrast agent in the artery is substantially a maximum relative to a concentration of contrast agent in adjacent veins and background tissue.

15. The method of claim 14 wherein the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by bolus injection.

16. The method of claim 14 wherein the step of collecting image data which is representative of the center of k-space includes collecting the image data while a flip angle is between about 20°

to about 9°

, TR≦

30 milliseconds and TE≦

7 milliseconds.

17. The method of claim 14 wherein the step of collecting data which is representative of the center of k-space includes using a 3D gradient echo pulse sequence.

18. The method of claim 17 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

19. The method of claim 14 wherein the step of collecting the image data which is representative of the center of k-space further includes collecting at least a portion of the data after a signal intensity from a region of interest increases by more than about 50%.

20. The method of claim 14 wherein the step of collecting image data further includes collecting at least 25% of the data which is representative of the center of k-space while the concentration of contrast agent in the artery is substantially higher than the concentration of contrast agent in adjacent veins and background tissue.

21. The method of claim 14 further including:

collecting pre-contrast image data prior to administering a magnetic resonance contrast agent to the patient, and

generating final image data of the artery using the pre-contrast image data and the image data which is representative of at least a portion of a center of k-space.

22. A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the method comprising,

administering magnetic resonance contrast agent to the patient by intravenous injection;

and

collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially a maximum relative to a concentration of contrast agent in adjacent veins and background tissue.

23. The method of claim 22 wherein the step of administering a magnetic resonance contrast agent to the patient includes administering the contrast agent to the patient by bolus injection.

24. The method of claim 22 wherein the step of collecting image data which is representative of the center of k-space includes collecting the image data while a flip angle is between about 20°

to about 90°

, TR≦

30 milliseconds and TE≦

7 milliseconds.

25. The method of claim 22 wherein the step of collecting data which is representative of the center of k-space includes using a 3D gradient echo pulse sequence.

26. The method of claim 25 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

27. A method of imaging a portion of an artery in a patient using magnetic resonance imaging, the portion of the artery being within a region of interest, the method comprising,

administering magnetic resonance contrast agent to the patient by bolus injection;

and

performing a 3D gradient echo pulse sequence to image the portion of the artery including collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

28. The method of claim 27 wherein the step of collecting image data further includes collecting the image data while a flip angle is between about 20°

to about 90°

. TR≦

30 milliseconds and TE≦

7 milliseconds.

29. The method of claim 27 wherein the step of collecting image data further includes using a body coil.

30. The method of claim 27 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

31. The method of claim 27 further including:

collecting pre-contrast image data of the artery prior to administering a magnetic resonance contrast agent to the patient, and

generating final image data of the artery using the pre-contrast image data and the image data which is representative of at least a portion of a center of k-space.

32. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

administering a magnetic resonance contrast agent to the patient;

and

collecting image data which is representative of a substantial portion of a center of k-space while a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins and background tissue adjacent to the artery and while a flip angle is between about 20°

to about 90° and

a slice thickness is less than about 5 millimeters.

33. The method of claim 32 wherein the step of collecting data includes using a 3D gradient echo pulse sequence.

34. The method of claim 33 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

35. The method of claim 32 wherein the step of collecting image data further includes using a body coil.

36. The method of claim 32 wherein the step of administering the contrast agent to the patient further includes administering the contrast agent to allow redistribution of the contrast agent into the extravascular fluid compartment in a systemic capillary bed distal to the artery so that, during collection of the image data, the concentration of magnetic resonance contrast agent in the adjacent veins is significantly lower than the concentration of magnetic resonance contrast agent in the artery.

37. The method of claim 32 further including:

collecting pre-contrast image data of the artery prior to administering the contrast agent to the patient, and

generating final image data of the artery using the pre-contrast image data and the image data which is representative of at least a portion of a center of k-space.

38. The method of claim 32 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data using a coronally oriented imaging volume.

39. The method of claim 32 wherein the step of collecting image data which is representative of the center of k-space includes collecting image data while a field of view is greater than about 30 centimeters.