Programmable control and mounting system for transdermal drug applicator

• US 5,746,711 A
• Filed: 09/23/1996
• Issued: 05/05/1998
• Est. Priority Date: 01/05/1987
• Status: Expired due to Fees

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan, Rosen, Sanford
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): TAO, ELLEN
• Application Number:
  US08/717,642
• Time in Patent Office: 589 Days
• Field of Search: 604/20, 604/289-90, 607/149, 607/115, 128/690
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138,140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144). The device includes a computer (158) with the mounting structure(138,140) for receiving programmed instructions relative to the drug, and transmitting signals relative to the drug and the programmed instructions to the power supply (166) for regulating the generation of power and delivery of drug through the skin (144).

Claims

1. An electrically powered transdermal drug applicator that is adapted to be adhered to a mucous membrane of a body for the controlled, automatic delivery of at least one drug through the mucous membrane, comprising

applicator means having a mucous membrane-contacting surface and including at least one drug reservoir containing at least one drug;

power means electrically connected to said at least one drug reservoir at an electrode for delivery of said at least one drug,

circuit means completing an electrical circuit between said at least one drug reservoir and said power source by return through the mucous membrane when said transdermal drug applicator is in use;

programmable computer means for regulating the generation of power so as to provide the controlled, automatic delivery of said at least one drug through said mucous membrane; and

computer activating means connected to said at least one drug reservoir for operating programmed resources within said computer means, said computer activating means comprising cams which activate said programmable computer means.

2. The transdermal drug applicator according to claim 1, wherein said at least one drug reservoir comprises high and low zones of drug concentration.

3. The transdermal drug applicator according to claim 2, wherein said zones of drug concentration are separated by a semi-permeable membrane.

4. The transdermal drug applicator according to claim 1, wherein said computer means includes computer components, display means and a computer power source positioned in a computer housing case, the computer components being in electrical connection with said applicator means.

5. The transdermal drug applicator according to claim 4, including sensing means for monitoring chemical and physical changes in said skin so as to transmit signals relative to said changes to said computer means, said computer components being in electrical connection with said sensing means.

6. The transdermal drug applicator according to claim 4, wherein said computer components are disposed in a watch-like housing;

and includes elements for monitoring time including an LCD for displaying time on said LCD.

7. The transdermal drug applicator according to claim 6, wherein said computer components further include the elements for transmitting data to said LCD relative to the rate of drug delivery, said LCD being capable of displaying said data as a function of current generated by said power means.

8. The transdermal drug applicator according to claim 7, further including an electrical connection between said computer components and said power source, said computer components being capable of controlling the power delivered by said power source.

9. The transdermal drug applicator according to claim 1, further including independent sensing means for sensing physical and chemical changes at said skin, and being in electrical connection with said computer means.

10. The transdermal drug applicator according to claim 1, wherein said applicator means is removably connected to said computer means.

11. The transdermal drug applicator according to claim 1, further including current conditioning means connected serially to said power means to provide a constant current.

12. An electrically powered transdermal drug applicator that is adapted to be adhered to a mucous membrane of a body for the controlled, automatic delivery of at least one drug through the mucous membrane, comprising

applicator means having a mucous membrane-contacting surface and including at least one drug reservoir containing at least one drug;

power means electrically connected to said at least one drug reservoir at an electrode for delivery of said at least one drug;

circuit means completing an electrical circuit between said at least one drug reservoir and said power source by return through the mucous membrane when said transdermal drag applicator is in use;

programmable computer means for regulating the generation of power so as to provide the controlled, automatic delivery of said at least one drug through said mucous membrane; and

computer activating means connected to said at least one drug reservoir for operating programmed resources within said computer means, said computer activating means comprising a bar code which activates said programmable computer means.

13. The transdermal drug applicator according to claim 12 wherein said bar code activates said computer means according to a predetermined drug regimen.

14. The transdermal drug applicator according to claim 12 wherein said at least one drug reservoir comprises high and low zones of drug concentration.

15. The transdermal drug applicator according to claim 14 wherein said zones of drug concentration are separated by a semi-permeable membrane.

16. The transdermal drug applicator according to claim 12 wherein said computer means includes computer components, display means and a computer power source positioned in a computer housing case, the computer components being in electrical connection with said applicator means.

17. The transdermal drug applicator according to claim 16 including sensing means for monitoring chemical and physical changes in said skin so as to transmit signals relative to said changes to said computer means, said computer components being in electrical connection with said sensing means.

18. The transdermal drug applicator according to claim 16 wherein said computer components are disposed in a watch-like housing, said watch-like housing including elements for monitoring time and including an LCD for displaying time.

19. The transdermal drug applicator according to claim 18 wherein said computer components further include the elements for transmitting data to said LCD relative to the rate of drug delivery, said LCD being capable of displaying said data as a function of current generated by said power means.

20. The transdermal drug applicator according to claim 19 further including an electrical connection between said computer components and said power source, said computer components being capable of controlling the power delivery by said power source.

21. The transdermal drug applicator according to claim 12 further including independent sensing means for sensing physical and chemical changes at said skin, said independent sensing means being in electrical connection with said computer means.

22. The transdermal drug applicator according to claim 12 wherein said applicator means is removably connected to said computer means.

23. The transdermal drug applicator according to claim 12 further including current conditioning means connected serially to said power means to provide constant current.