Suspension of loteprednol etabonate for ear, eye, or nose treatment

• US 5,747,061 A
• Filed: 07/29/1996
• Issued: 05/05/1998
• Est. Priority Date: 10/25/1993
• Status: Expired due to Term

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Pharmos Corporation
• Inventors: Friedman, Doron, Amselem, Shimon
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US08/688,157
• Time in Patent Office: 645 Days
• Field of Search: 424/427, 424/437, 424/434, 424/489, 514/772.2-772.3, 514/772.5, 514/778, 514/914, 514/937
• US Class Current: 424/427
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 31/79 Polymers of vinyl pyrrolidone
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The invention provides novel compositions of matter for delivering water-insoluble steroid drugs suitable for therapeutic use. The invention also provides stable aqueous suspensions of water-insoluble steroid drugs of particle sizes of ≦30 μm which remain in such a state so as to allow for immediate suspension, when desired, even after extended periods of settling.

Claims

1. A composition for ophthalmic or otolaryngological anti-inflammatory use comprising:

(A) a corticosteroid in an amount of 0.01 to about 2% by weight and having a particle size of about 0.1 to 30 microns in diameter to substantially prevent discomfort upon use of the composition for said ophthalmic or otolaryngological anti-inflammatory treatment;

(B) a nonionic polymer in an aqueous medium;

(C) a nonionic tonicity agent in an amount sufficient to achieve isotonicity; and

(D) a nonionic surface active agent in an amount sufficient to retain the corticosteroid, the nonionic tonicity agent and the nonionic polymer in a suspension.

21. The composition of claim 1 wherein the nonionic polymer is present in an amount of between about 0.2 to about 2% by weight, the non-ionic tonicity agent is present in an amount of between about 1 to about 7% by weight, and the nonionic surface active agent is present in an amount of between about 0.05 to about 1% by weight, and wherein the molar ratio of (A):

(B);

(D) is about 1;

0.01;

0.05 to about 1;

20;

1.

22. The composition of claim 1 wherein said nonionic polymer is a water soluble polymer selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, dextran and cyclodextrin.

23. The composition of claim 1 wherein the nonionic polymer is present in an amount of about 0.2 to 2% by weight.

24. The composition of claim 1 wherein the nonionic tonicity agent is present in an amount of between about 1 to about 7% by weight.

25. The composition of claim 1 wherein said nonionic tonicity agent is a nonionic polyol.

26. The composition of claim 1 wherein said nonionic surface active agent is present in an amount of about 0.05 to about 1% by weight.

27. The composition of claim 1, wherein said nonionic surface active agent is tyloxapol or a polyoxyethylene sorbitan mono-oleate ester.

28. The composition of claim 1 including a preservative in an amount of between about 0.0001 and about 0.025% by weight for preventing microbial formation in said composition.

29. The composition of claim 28 wherein said preservative is selected from the group consisting of benzalkonium chloride, disodium edetate and mixtures thereof.

2. A composition for ophthalmic or otolaryngological anti-inflammatory use comprising:

(A) a corticosteroid in an amount of about 0.01% to about 2% by weight, said corticosteroid having a particle size of about 0.1 to 30 microns diameter to substantially prevent discomfort upon use of the composition for said ophthalmic or otolaryngological anti-inflammatory applications;

(B) a nonionic polymer in an aqueous medium;

(C) a nonionic tonicity agent in an amount sufficient to achieve isotonicity; and

(D) a nonionic surface active agent in an amount sufficient to retain the corticosteroid, the nonionic tonicity agent and the nonionic polymer in suspension,

wherein the molar ratio of (A);

(B);

(D) is about 1;

0.01;

0.05 to about 1;

20;

1.

3. The composition of claim 2 wherein the corticosteroid is selected from the group consisting of soft steroids having anti-inflammatory activity and is present in an amount of between about 0.01 and 1% by weight.

4. The composition of claim 2 wherein the corticosteroid is loteprednol etabonate and is present in an amount of between about 0.05 and about 0.5% by weight.

5. The composition of claim 2 wherein said nonionic polymer is a water soluble polymer selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, dextran and cyclodextrin.

6. The composition of claim 2 wherein the nonionic polymer is present in an amount of about 0.2 to 2% by weight.

7. The composition of claim 5, wherein said nonionic polymer is polyvinylpyrrolidone and is present in an amount of between about 0.3 to about 1.75% by weight.

8. The composition of claim 2 wherein said nonionic surface active agent is tyloxapol and is present in an amount of about 0.05 to about 1% by weight.

9. The composition of claim 2, wherein said nonionic surface active agent is a polyoxyethylene sorbitan mono-oleate ester.

10. The composition of claim 7 wherein the nonionic tonicity agent is present in an amount of between about 1 to about 7% by weight.

11. The composition of claim 10 wherein said non-ionic tonicity agent is a nonionic polyol and is present in an amount of between about 1.5 to about 4% by weight.

12. The composition of claim 2 wherein said polyol is glycerol or mannitol.

13. The composition of claim 2 further including a preservative for preventing microbial formation in said composition and is present in an amount of between about 0.0001 to about 0.025% by weight.

14. The composition of claim 13 wherein said preservative is selected from the group consisting of benzalkonium chloride, disodium edetate and mixtures thereof.

15. The composition of claim 2 further comprising an additional therapeutic drug in admixture with said corticosteroid, wherein said additional therapeutic drug is selected from the group consisting of betaxolol, atenolol, levobunolol, epinephrin, dipivalyl, oxonolol, acetazolamide-base, methazolamide, tobramycin, gentamycin, piroxicam, indomethacin, naproxen, phenylbutazone, ibuprofen, and diclofenac.

16. The composition of claim 2 wherein the nonionic polymer is present in an amount of between about 0.2 to about 2% by weight;

the nonionic tonicity agent is present in an amount of between about 1 to about 7% by weight; and

the nonionic surface active agent is present in an amount of between about 0.05 to about 1% by weight.

17. The composition of claim 16 further comprising a preservative for preventing microbial formation in said composition and is present in an amount of about 0.0001 to 0.025% by weight.

20. The composition of claim 2 wherein the corticosteroid has a mean particle size of ≦

15 μ

m.

18. A method for treating ophthalmic or otolaryngological inflammation which comprises applying to inflamed tissue a composition comprising:

(A) a corticosteroid in an amount of 0.01 to about 2% by weight and having a particle size of about 0.1 to 30 microns in diameter to substantially prevent discomfort upon use of the composition for said ophthalmic or otolaryngological anti-inflammatory treatment;

(B) a nonionic polymer in an aqueous medium;

(C) a nonionic tonicity agent in an amount sufficient to achieve isotonicity; and

(D) a nonionic surface active agent in an amount sufficient to retain the corticosteroid, the nonionic tonicity agent and the nonionic polymer in a suspension,

wherein said composition is applied in an amount effective to treat said inflammation.

19. The method of claim 18 wherein the nonionic polymer is present in an amount of between about 0.2 to about 2% by weight, the non-ionic tonicity agent is present in an amount of between about 1 to about 7% by weight, and the nonionic surface active agent is present in an amount of between about 0.05 to about 1% by weight, and wherein the molar ratio of (A):

(B);

(D) is about 1;

0.01;

0.05 to about 1;

20;

1.

30. The method of claim 18 wherein the molar ratio of (A):

(B);

(D) is about 1;

0.01;

0.05 to about 1;

20;

1 when the corticosteroid is present.