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Amino acid derivatives

  • US 5,747,522 A
  • Filed: 05/25/1995
  • Issued: 05/05/1998
  • Est. Priority Date: 03/26/1991
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula ##STR19## wherein L is a group of the formula ##STR20## or


  • space="preserve" listing-type="equation">R.sup.o -NH(CH.sub.2).sub.t L.sup.2
R is amidino or guanidino, each of X and Y is CH,Ro is hydrogen or amidino,t is an integer between 2 and 6,R'"'"' and R" together with the N atom and C atom to which they are attached form an optionally substituted 4- to 6-membered ring;

R"'"'"' is hydrogen or optionally substituted lower alkyl;

Q is a group of the formula ##STR21##


space="preserve" listing-type="equation">--N(V'"'"')CH.sub.2 .sub.v --C(V",V'"'"'")CH.sub.2 OCH.sub.2 COO-T Q.sup.8or ##STR22## n is the number 0 or 1, v is an integer between 0 and 3,T and T'"'"' are hydrogen or a lower-alkyl or phenyl-lower-alkyl group which is cleavable under physiological conditions,V to V"'"'"' are hydrogen or lower-alkyl,U and U'"'"' are hydrogen, C1-6 alkanoyl or aroyl,Ar is aryl andR2 to R5 are hydrogen, lower-alkyl, lower-alkoxy, halogen or a group --OCH2 COO-T'"'"' orR2 and R3 together with the phenyl group to which they are attached form a 1-naphthyl group,as well as hydrates or solvates and physiologically usable salts thereof.

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