Separation of the enantiomers of amlodipine via their diastereomeric tartrates
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Abstract
A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO) for the precipitation of, respectively, a DMSO solvate of an L-tartrate salt of R-(+)-amlodipine, or a DMSO solvate of a D-tartrate salt of S-(-)-amlodipine. ##STR1##
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4 Claims
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1. (S)-(-)-Amlodipine-hemi-D-tartrate-mono-DMSO-solvate.
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2. (R)-(+)-Amlodipine-hemi-L-tartrate-mono-DMSO-solvate.
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3. (S)-(-)-Amlodipine-hemi-D-tartrate-monohydrate.
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4. (R)-(+)-Amlodipine-hemi-L-tartrate-monohydrate.
Specification