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Use of paramagnetic compounds to measure temperature and pH in vivo

  • US 5,753,207 A
  • Filed: 08/19/1996
  • Issued: 05/19/1998
  • Est. Priority Date: 08/21/1995
  • Status: Expired due to Fees
First Claim
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1. A method for measuring temperature change in a biological tissue, said method comprising:

  • (a) administering a lanthanide paramagnetic complex to said biological tissue;

    (b) subjecting said biological tissue to a magnetic field;

    (c) measuring the chemical shift caused by said magnetic field; and

    (d) calculating the temperature of said biological tissue from said chemical shift.wherein said lanthanide paramagnetic complex has a temperature dependence of the 1 H chemical shift in the range of about 0.15 to about 2.00 ppm/°

    C. or said lanthanide paramagnetic complex has a temperature dependence of the 31 P chemical shift in the range of about 0.01 to about 4.00 ppm/°

    C.

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