Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
First Claim
1. A method of treating atherosclerosis comprising a step of placing in an extracorporeal adsorption device at least one chelant which binds selectively with a metal ion oxidant, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing said metal ion to said chelant.
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Abstract
Extracorporeal affinity adsorption treatments which are aimed at the substantial removal of two or more compounds that are etiological in the pathogenesis of diseases in man provide effective therapeutic intervention means for these diseases. The methods are particularly suitable for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases. Extracorporeal chelation and immunotherapy for atherosclerosis, extracorporeal chelation treatment with on-line regeneration or replacement of chelant, extracorporeal immunotherapy with antibody fragments, and extracorporeal immunoadsorption utilizing antibodies bound to Protein A are also disclosed.
128 Citations
62 Claims
- 1. A method of treating atherosclerosis comprising a step of placing in an extracorporeal adsorption device at least one chelant which binds selectively with a metal ion oxidant, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing said metal ion to said chelant.
- 7. A method of treating atherosclerosis comprising a step of placing in an extracorporeal affinity adsorption device at least two specific affinity adsorbents, one of said specific affinity adsorbents binding selectively with a first chemical species which is etiological to atherosclerosis and a second of said specific affinity adsorbents binding selectively with a second chemical species which is etiological to atherosclerosis, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing both said chemical species to said specific affinity adsorbents.
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9. An extracorporeal device for treating a disease state in a living mammal, the disease state being characterized by having a first chemical species comprising a metal ion oxidant etiological to the disease state or its symptoms and a second chemical species which is etiological to the disease state or to its symptoms, the device including means for drawing from the mammal a fluid containing the metal ion oxidant and the second chemical species, means for exposing the fluid to at least a first chelant binding means for chemically binding said metal ion oxidant in said device and to a second binding means for chemically binding said second chemical species in said device, and means for returning to the mammal at least a fraction of said fluid.
- 10. A method for treating a disease state in a living mammal, the disease state being characterized by having a first chemical species comprising a metal ion oxidant etiological to the disease state or its symptoms and a second chemical species which is etiological to the disease state or to its symptoms, the method comprising drawing from the mammal a fluid containing the metal ion oxidant and the second chemical species into an extracorporeal device, exposing the fluid to at least a chelant for chemically binding said first chemical species in said device, exposing the fluid to a specific affinity adsorbent for chemically binding said second chemical species in said device, and returning to the mammal at least a fraction of said fluid.
- 21. A method for treating a disease state in a living mammal, the disease state being characterized by having at least a first chemical species and a second chemical species which are etiological to the disease state or to its symptoms, the method comprising drawing from the mammal a fluid containing both the chemical species into an extracorporeal device, exposing the fluid to at least a first specific affinity adsorbent for chemically binding said first chemical species in said device, exposing the fluid to a second specific affinity adsorbent for chemically binding said second chemical species in said device, returning to the mammal at least a fraction of said fluid, and a further step of administering to the living mammal intravenously at least one plasma component.
- 23. A method of treating atherosclerosis comprising a step of placing in an extracorporeal affinity adsorption device at least one chemical substance which binds selectively with autoantibodies to oxidized low density lipoproteins, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing autoantibodies to oxidized low density lipoproteins to said chemical substance.
- 25. An extracorporeal device including means for drawing from a mammal a fluid, chelant means in said device for exposing at least a portion of the fluid to a chelating agent for binding a metal ion and a specific affinity adsorbent in said device for chemically binding at least one chemical species in said fluid, and means for returning to the mammal at least a fraction of said fluid.
- 47. A method for treating a disease state in a living mammal, the disease state being characterized by having at least a first chemical species and a second chemical species which are etiological to the disease state or to its symptoms, the method comprising drawing from the mammal a fluid containing both the chemical species into an extracorporeal device exposing the fluid to at least a first adsorbent for chemically binding the first chemical species in the device and to a second adsorbent for chemically binding the second chemical species in the device returning to the mammal at least a fraction of the fluid, and thereafter regenerating the device for further use by connecting a regenerating fluid to the device at least one of the adsorbents being a specific affinity adsorbent, the other adsorbent being a chelant.
- 54. A method for treating a disease state in a living mammal, the disease state being characterized by having at least a first chemical species and a second chemical species which are etiological to the disease state or to its symptoms, the method comprising drawing from the mammal a fluid containing both the chemical species into an extracorporeal device, exposing the fluid to at least a first adsorbent for chemically binding selectively with the first chemical species in the device and to a second adsorbent for chemically binding selectively with the second chemical species in the device, returning to the mammal at least a fraction of the fluid, and thereafter regenerating the device for further use by connecting a regenerating fluid to the device, wherein the disease state is atherosclerosis.
- 56. A method for treating a disease state in a living mammal, the disease state being characterized by having at least a first chemical species and a second chemical species which are etiological to the disease state or to its symptoms, the method comprising drawing from the mammal a fluid containing both the chemical species into an extracorporeal device, exposing the fluid to at least a first adsorbent for chemically binding the first chemical species in the device and to a second adsorbent for chemically binding the second chemical species in the device, returning to the mammal at least a fraction of the fluid, and thereafter regenerating the device for further use by connecting a regenerating fluid to the device, and a further step of administering to the living mammal intravenously at least one plasma component.
- 58. A method of treating a disease state selected from the group consisting of cancer and autoimmune disease, the method comprising a step of placing in an extracorporeal adsorption device at least one chelant which binds selectively with a metal ion oxidant, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing said metal ion to said chelant.
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62. A method of treating an autoimmune disease, the method comprising a step of placing in an extracorporeal adsorption device at least one chelant which binds selectively with a metal ion oxidant, and a step of connecting the device in the blood circulatory system of a mammal to expose at least a portion of the blood of the mammal containing said metal ion to said chelant.
Specification