Photolabile nucleoside protecting groups
First Claim
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1. A compound comprising the following structure:
- ##STR25## wherein;
n is either 0 or 1;
Y is selected from the group consisting of carboxyl group of an amino acid and hydroxyl group of a nucleoside or nucleotide;
R1 and R2 are selected independently from the group consisting of;
lower alkyl, aryl, benzyl, halogen, hydroxyl, alkoxyl, thio, thioether, amino, nitro, carboxyl, formate, formamido, hydrogen, or phosphido; and
R3 is selected from the group consisting of alkoxy, alkyl, aryl, hydrogen, or alkenyl.
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Abstract
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
150 Citations
46 Claims
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1. A compound comprising the following structure:
- ##STR25## wherein;
n is either 0 or 1;Y is selected from the group consisting of carboxyl group of an amino acid and hydroxyl group of a nucleoside or nucleotide; R1 and R2 are selected independently from the group consisting of;
lower alkyl, aryl, benzyl, halogen, hydroxyl, alkoxyl, thio, thioether, amino, nitro, carboxyl, formate, formamido, hydrogen, or phosphido; andR3 is selected from the group consisting of alkoxy, alkyl, aryl, hydrogen, or alkenyl. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
- ##STR25## wherein;
Specification