Method for controlled contraction of collagen tissue

• US 5,755,753 A
• Filed: 05/05/1995
• Issued: 05/26/1998
• Est. Priority Date: 05/05/1995
• Status: Expired due to Term

• Current Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Inventors: Knowlton, Edward W.
• Primary Examiner(s): Bahr, Jennifer
• Assistant Examiner(s): YARNELL, BRYAN KEITH
• Application Number:
  US08/435,822
• Time in Patent Office: 1,117 Days
• Field of Search: 607/96-104, 607/115, 607/154, 607/108, 607/109, 606/2, 606/9, 606/33, 606/41, 606/32, 606/34
• US Class Current: 607/98
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/0066 without feedback, i.e. open loop control
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment

Abstract

A method and apparatus applies radiant energy through the skin to underlying collagen tissue without substantially modifying melanocytes and other epithelial cells in the epidermis. A porous membrane is adapted to receive an electrolytic solution and become inflated to substantially conform a contacting exterior surface of the membrane to a skin layer. The membrane includes a cooling lumen for receiving cooling fluid. One or more thermal electrodes is positioned in the membrane and transfers thermal energy to the electrolytic solution. The electrolytic solution and cooling fluid creates a reverse thermal gradient from the skin surface to the underlying collagen tissue. A thermal power source is coupled to the thermal electrodes, and a source of electrolytic solution is coupled to the membrane.

Claims

1. A method for tightening skin, comprising:

providing an electromagnetic energy delivery device;

positioning an energy delivery surface of the electromagnetic energy delivery device on an external surface of the skin;

creating a reverse thermal gradient through a surface of the skin while heating underlying collagen containing tissue, wherein a temperature of the external skin surface is lower than a temperature of the underlying collagen containing tissue;

heating the surface of the skin and underlying collagen containing tissue without creating a necrosis of living cells in the epidermis;

contracting at least a portion of the collagen containing tissue and

tightening at least a portion of the surface of the skin.

2. The method of claim 1, wherein the collagen containing tissue is partially denatured by cleaving heat labile cross-links of collagen molecules.

3. The method of claim 2, wherein the collagen containing tissue is partially denatured while minimizing cellular destruction.

4. The method of claim 3, wherein the collagen containing tissue is in a subdermal layer.

5. The method of claim 3, wherein the collagen containing tissue is in a deep dermal layer.

6. The method of claim 3, wherein the collagen containing tissue is in a subcutaneous layer.

7. The method of claim 3, wherein the collagen containing tissue is in facial and muscle tissue.

8. The method of claim 2, wherein the reverse thermal gradient produces a net mobilization of intracellular fat with diminished destruction of cells.

9. The method of claim 1, wherein the electromagnetic energy source is a RF power source and one or more RF electrodes positioned on a surface of the skin.

10. The method of claim 9, further comprising:

a source of electrolytic solution that delivers electrolytic solution to the RF electrode.

11. The method of claim 10, wherein RF energy is transferred from the RF electrodes to the electrolytic solution.

12. The method of claim 11, further comprising:

a cooling fluid lumen positioned in the electrode.

13. The method of claim 12, further comprising

a source of cooling medium that is introduced into the cooling fluid lumen.

14. The method of claim 1, wherein the collagen containing tissue is heated to a temperature not exceeding 80 degrees C.

15. The method of claim 1, wherein the collagen containing tissue is heated to a temperature not exceeding 75 degrees C.

16. The method of claim 1, wherein the collagen containing tissue is heated to a temperature not exceeding 70 degrees C.

17. A method for tightening skin, comprising:

providing an electromagnetic energy delivery device;

positioning an energy delivery surface of the electromagnetic energy delivery device on an external surface of the skin;

creating a reverse thermal gradient through a surface of the skin while heatino underlying collagen containing tissue, wherein a temperature of the external skin surface is lower than a temperature of the underlying collagen containing tissue; and

controlling a delivery of a sufficient amount of electromagnetic energy through an epidermis of the external surface of the skin to reconfigure at least a portion of an underlying collagen containing tissue without substantially creating cell necrosis in the epidermis, wherein at least a portion of the surface of the skin is tightened.

18. The method of claim 17, wherein the collagen containing tissue is partially denatured by cleaving heat labile cross-links of collagen molecules.

19. The method of claim 18, wherein the collagen containing tissue is partially denatured while minimizing cellular destruction.

20. The method of claim 17, wherein the electromagnetic energy source is an RF power source coupled to one or more RF electrodes.

21. The method of claim 17, further comprising:

providing a source of electrolytic solution coupled to the surface of the skin.

22. The method of claim 21, wherein RF energy is transferred from the RF electrodes to the electrolytic solution.

23. The method of claim 17, further comprising:

a cooling fluid lumen coupled to the electromagnetic energy delivery device.

24. The method of claim 23, further comprising

a source of cooling medium coupled to the cooling fluid lumen.

25. The method of claim 17, wherein the collagen containing tissue is in a subdermal layer.

26. The method of claim 17, wherein the collagen containing tissue is in a deep dermal layer.

27. The method of claim 17, wherein the collagen containing tissue is in a subcutaneous layer.

28. The method of claim 17, wherein the collagen containing tissue is in facial and muscle tissue.

29. The method of claim 17, wherein the collagen containing tissue is heated to a temperature not exceeding 80 degrees C.

30. The method of claim 17, wherein the collagen containing tissue is heated to a temperature not exceeding 75 degrees C.

31. The method of claim 17, wherein the collagen containing tissue is heated to a temperature not exceeding 70 degrees C.

32. A method for tightening skin, comprising:

providing an electromagnetic energy delivery device;

positioning an energy delivery surface of the electromagnetic energy delivery device on an external surface of the skin;

creating a reverse thermal gradient through a surface of the skin while heating underlying collagen containing tissue, wherein a temperature of the external skin surface is lower than a temperature of the underlying collagen containing tissue; and

controlling a delivery of a sufficient amount of electromagnetic energy through an epidermis of the surface of the skin to reconfigure at least a portion of an underlying collagen containing tissue without substantially creating cell necrosis in the collagen containing tissue, wherein at least a portion of the surface of the skin is tightened.

33. A method for tightening skin, comprising:

providing an electromagnetic energy delivery device;

positioning the electromagnetic energy delivery device on an external surface of the skin;

creating a reverse thermal gradient through a surface of the skin while heating underlying collagen containing tissue, wherein a temperature of the external skin surface is lower than a temperature of the underlying collagen containing tissue; and

controlling a delivery of a sufficient amount of electromagnetic energy through an epidermis of the surface of the skin to reconfigure at least a portion of an underlying collagen containing tissue without substantially creating cell necrosis in an epidermis of the skin and the collagen containing tissue, wherein at least a portion of the surface of the skin is tightened.