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Methods of producing singlet oxygen using compounds having improved functionalization

  • US 5,756,726 A
  • Filed: 06/06/1995
  • Issued: 05/26/1998
  • Est. Priority Date: 06/02/1995
  • Status: Expired due to Fees
First Claim
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1. A method of producing light-induced singlet oxygen, the method comprising subjecting a texaphyrin to light in the presence of oxygen, wherein the texaphyrin has the structure:

  • ##STR14## wherein M is a diamagnetic metal cation;

    R1 -R4, R7 and R8 are independently hydrogen, halide, hydroxyl, alkyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, carboxy, carboxyalkyl, carboxyamidealkyl, a site-directing molecule, a catalytic group, or a couple to a site-directing molecule or to a catalytic group;

    R6 and R9 are independently selected from the groups of R1 -R4, R7 and R8, with the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl;

    R5 and R10 -R12 are independently hydrogen, alkyl, aryl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, carboxyalkyl, carboxyamidealkyl or a couple to a saccharide, to a site-directing molecule or to a catalytic group;

    at least one of R5, R6, R9, R10, R11 and R12 is other than hydrogen; and

    Z is an integer less than or equal to 5.

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