Apparatus and process for preparing radioisotope-labeled reagent
First Claim
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1. An apparatus for preparing a radioisotope-labeled reagent comprising a hermetically sealed unit, comprising:
- a plurality of raw material-holding containers;
a plurality of reaction vessels;
a plurality of columns;
at least one liquid transfer pump;
a plurality of transfer tubes forming connections among said containers, vessels, columns and pumps;
shut-off cocks disposed in the containers, vessels, columns, or connections;
at least one raw material disposed in at least one of said containers, vessels or columns, wherein said material is held within the hermetically sealed unit; and
a source of force-fed gas connected to at least one of said containers, vessels, columns and tubes, wherein sources of force-fed gas and pressure reduction can be connected through respective shut-off cocks in order that liquids may be transferred to the intended containers and reaction vessels by means of a non-reactive gas for force-fed and pressure reduction, wherein said radioisotope-labeled reagent comprises, as a label, a radioactive atoms of relatively short half-life selected from the group consisting of 11 C, 15 O, 13 N and 18 F.
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Abstract
Apparatus and process for non-pyrogenously preparing a radioisotope-labeled reagent that includes a plurality of raw material-holding containers, reaction vessels, and columns connected to each other by transfer tubes that are hermetically sealed such that the raw materials can be introduced into the appropriate reaction vessels in the appropriate order through the transfer tubes using a force fed inert gas.
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Citations
6 Claims
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1. An apparatus for preparing a radioisotope-labeled reagent comprising a hermetically sealed unit, comprising:
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a plurality of raw material-holding containers; a plurality of reaction vessels; a plurality of columns; at least one liquid transfer pump; a plurality of transfer tubes forming connections among said containers, vessels, columns and pumps; shut-off cocks disposed in the containers, vessels, columns, or connections; at least one raw material disposed in at least one of said containers, vessels or columns, wherein said material is held within the hermetically sealed unit; and a source of force-fed gas connected to at least one of said containers, vessels, columns and tubes, wherein sources of force-fed gas and pressure reduction can be connected through respective shut-off cocks in order that liquids may be transferred to the intended containers and reaction vessels by means of a non-reactive gas for force-fed and pressure reduction, wherein said radioisotope-labeled reagent comprises, as a label, a radioactive atoms of relatively short half-life selected from the group consisting of 11 C, 15 O, 13 N and 18 F. - View Dependent Claims (2, 3)
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4. A process for preparing a radioisotope-labeled reagent, comprising:
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introducing raw materials into a hermetically sealed unit containing containers, vessels, and columns and hermetically holding the raw materials in the containers, vessels, and columns; transferring the raw materials to appropriate reaction vessels and columns by means of force-fed non-reactive gas, pressure reduction and liquid transfer pumps, wherein the appropriate reaction vessels and columns are connected to the containers by transfer tubes; and controlling said transferring of materials by means of shut-off cocks for connection, shut-off cocks for force-fed gas, shut-off cocks for pressure reduction and operation of liquid transfer pumps wherein said radioisotope-labeled reagent comprises, as a label, a radioactive atom of relatively short half-life selected from the group consisting of 11 C, 15 O, 13 N and 18 F. - View Dependent Claims (5, 6)
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Specification