Iontophoretic material

• US 5,759,564 A
• Filed: 04/16/1996
• Issued: 06/02/1998
• Est. Priority Date: 04/16/1996
• Status: Expired due to Term

• Current Assignee: Bridge Blood Technologies LLC
• Original Assignee: Implemed, Inc.
• Inventors: Anderson, Donald, Milder, Frederic L., Weitzner, Barry D.
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US08/633,222
• Time in Patent Office: 777 Days
• Field of Search: 424/423, 424/449, 424/426, 604/20
• US Class Current: 424/426
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2002/30052 differing in electric or magnetic properties
• CPC Class Codes: A61F 2002/30064 Coating or prosthesis-covering structure made of biodegradable material
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30929 having at least two superposed coatings
• CPC Class Codes: A61F 2250/0043 differing in electric properties, e.g. in electrical conductivity, in galvanic properties
• CPC Class Codes: A61F 2310/00113 Silver or Ag-based alloys
• CPC Class Codes: A61F 2310/00149 Platinum or Pt-based alloys
• CPC Class Codes: A61F 2310/0052 Coating made of silver or Ag-based alloys
• CPC Class Codes: A61F 2310/00562 Coating made of platinum or Pt-based alloys

Abstract

An iontophoretic material is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill microorganisms on and near the material. Iontophoretic structures or material associated with a medical device are partially or completely covered with one or more covering layers that alter physical, mechanical, chemical, or biological properties of the device and/or the iontophoretic material. In addition to being partially coated or completely enveloped by iontophoretic material or structures, all or a portion of a medical device can be integrated with, impregnated by, or fabricated from an iontophoretic material.

Claims

1. An iontophoretic structure comprising:

an iontophoretic material comprising one of an iontophoretic composite material and a layered iontophoretic structure; and

a covering layer disposed on a surface portion of the iontophoretic material.

2. The iontophoretic structure of claim 1, wherein said covering layer is chemically bonded to said iontophoretic material.

3. The iontophoretic structure of claim 1, wherein said covering layer is mechanically attached to said iontophoretic material.

4. The iontophoretic structure of claim 1, wherein said covering layer is merged with said iontophoretic material.

5. The iontophoretic structure of claim 1, wherein said covering layer is permeable.

6. The iontophoretic structure of claim 5, wherein said covering layer includes a hydrophilic substance.

7. The iontophoretic structure of claim 5, wherein said covering layer includes one of a blood thinner and an anticoagulant.

8. The iontophoretic structure of claim 5, wherein said covering layer includes a polymer.

9. The iontophoretic structure of claim 5, further including a coating covering at least of portion of said permeable covering layer.

10. The iontophoretic structure of claim 9, wherein said coating includes a biodegradable material.

11. The iontophoretic structure of claim 10, wherein said coating includes one of a chemical and a biological agent that is liberated from said coating when said biodegradable material degrades.

12. The iontophoretic structure of claim 9, wherein said coating includes a liquid soluble material.

13. The iontophoretic structure of claim 12, wherein said coating includes one of a chemical and a biological agent that is liberated from said coating when said liquid soluble material dissolves.

14. The iontophoretic structure of claim 9, wherein said coating further includes pigmentation.

15. The iontophoretic structure of claim 9, wherein said covering layer and said coating are merged to provide a single layer that covers at least a portion of said iontophoretic material.

16. The iontophoretic structure of claim 5, further comprising a substrate that is at least partially covered by said iontophoretic material.

17. The iontophoretic structure of claim 5, further comprising a substrate that is completely enveloped by said iontophoretic material.

18. The iontophoretic structure of claim 5, wherein said iontophoretic structure has an irregular surface and said covering layer imparts a smooth surface to said iontophoretic structure.

19. The iontophoretic structure of claim 1, wherein said covering layer includes a biodegradable material.

20. The iontophoretic structure of claim 19, wherein said covering layer includes one of a chemical and a biological agent that is liberated from said coating when said biodegradable material degrades.

21. The iontophoretic structure of claim 1, wherein said covering layer includes a liquid soluble material.

22. The iontophoretic structure of claim 21, wherein said covering layer includes one of a chemical and a biological agent that is liberated from said coating when said liquid soluble material dissolves.

23. The iontophoretic structure of claim 1, wherein said covering layer further includes pigmentation.

24. The iontophoretic structure of claim 1, wherein said covering layer imparts lubricity to said iontophoretic structure.

25. The iontophoretic structure of claim 1, wherein said covering layer is wear and fatigue resistant.