Multi-layer wound dressing

• US 5,759,570 A
• Filed: 11/07/1996
• Issued: 06/02/1998
• Est. Priority Date: 11/23/1992
• Status: Expired due to Fees

• Current Assignee: Systagenix Wound Management Ip Co., B.V (3M Company)
• Original Assignee: Johnson & Johnson Medical Incorporated (Johnson & Johnson)
• Inventors: Arnold, Peter Stuart
• Primary Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US08/745,112
• Time in Patent Office: 572 Days
• Field of Search: 424/493, 424/443, 424/445, 604/304
• US Class Current: 424/443
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 13/023 wound covering film layers without a fluid retention layer
• CPC Class Codes: A61F 13/15252 compostable or biodegradable
• CPC Class Codes: A61F 2013/00731 with absorbing pads
• CPC Class Codes: A61F 2013/00748 with hydrocolloids or superabsorbers
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61F 2013/00927 with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
• CPC Class Codes: A61L 15/24 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/30 Rubbers or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/325 Collagen
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2300/414 Growth factors

Abstract

The invention provides wound dressings comprising a molecular filtration membrane having a maximum pore size in the range of from 0.001 μm to 0.5 μm, and preferably in the range of from 0.01 μm to 0.25 μm. The wound dressings may also comprise an absorbent layer atop the molecular filtration membrane and/or a wound contact layer of wound-friendly bioabsorbable material for contacting the wound. In use, the molecular filtration membrane retains high molecular weight biopolymers and wound healing factors at the wound surface while excluding bacteria and allowing rapid egress of wound exudate through the membrane into the absorbent layer.

Claims

1. A wound dressing comprising:

a wound contacting layer comprising a bioabsorbable and hydrophilic polymeric material that forms a gel in contact with wound exudate.

a liquid permeable molecular filtration membrane, having a maximum pore size in the range of from 0.001 μ

m to 0.5 μ

m;

an absorbent layer overlying the molecular filtration membrane and comprising a pharmaceutical, a wound healing agent, a growth factor or a microbiocide capable of passing through the molecular filtration membrane; and

an outer protective membrane overlying the absorbent layer on the side opposite from the molecular filtration membrane.

2. The wound dressing of claim 1, wherein the molecular filtration membrane has a maximum pore size in the range of from 0.01 μ

m to 0.5 μ

m.

3. The wound dressing of claim 1, wherein the molecular filtration membrane has a maximum pore size in the range of from 0.01 μ

m to 0.25 μ

m.

4. The wound dressing of claim 1, wherein the molecular filtration membrane has a pore size in the range of from 0.02 μ

m to 0.2 μ

m.

5. The wound dressing of claim 1, wherein the molecular filtration membrane is selected from the group consisting of polysulfone, Nylon 66, cellulose, a cellulosic compound, polyvinylidene fluoride, polyurethane, PTFE, polylactic acid, polyglycolic acid, or copolymers thereof and mixtures thereof.

6. The wound dressing of claim 1 wherein the outer protective membrane is semipermeable.

7. The wound dressing of claim 1 wherein the outer protective membrane extends beyond the molecular filtration membrane and the intermediate absorbent layer, and is provided with an adhesive coating for attaching the wound dressing to mammalian skin in the vicinity of a wound.

8. The wound dressing of claim 1 wherein the biocompatible wound contact material is selected from the group consisting of collagen, chitin, fibrin, laminin, fibronectin, an alginate, a glycosaminoglycan, and mixtures thereof.

9. The wound dressing of claim 1 wherein the biocompatible wound contact material comprises a polyhydric alcohol.

10. The wound dressing of claim 1 wherein the biocompatible wound contact material comprises collagen and a glycosaminoglycan.

11. The wound dressing of claim 1 which is sterile.

12. The wound dressing of claim 1 wherein a marginal portion of the wound dressing membrane is coated with an adhesive layer for attaching the wound dressing to mammalian skin.

13. The wound dressing of claim 12 further comprising a release-coated protective membrane to protect said adhesive layer prior to using the wound dressing.