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Multiparametric fluorescence in situ hybridization

  • US 5,759,781 A
  • Filed: 05/01/1996
  • Issued: 06/02/1998
  • Est. Priority Date: 12/22/1995
  • Status: Expired due to Term
First Claim
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1. A set of combinatorially labeled oligonucleotide probes, each member thereof comprising a plurality of an oligonucleotide, said oligonucleotide:

  • (i) being linked or coupled to a predetermined label distinguishable from the label of any other member of said set, and (ii) being capable of specifically hybridizing with one predetermined autosomal or sex chromosome of a human karyotype;

    said set having sufficient members to be capable of specifically hybridizing each autosomal or sex chromosome of said human karyotype to at least one member.

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