Anticonvulsant derivatives useful in treating psoriasis
First Claim
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1. A method for treating psoriasis comprising administering to a human afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I:
- ##STR7## wherein X is CH2 or oxygen;
R1 is hydrogen or alkyl; and
R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II);
##STR8## wherein R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
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Abstract
The use of compounds of the following formula I: ##STR1## for treating psoriasis is disclosed.
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Citations
4 Claims
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1. A method for treating psoriasis comprising administering to a human afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I:
- ##STR7## wherein X is CH2 or oxygen;
R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II);
##STR8## wherein R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring. - View Dependent Claims (2, 3, 4)
- ##STR7## wherein X is CH2 or oxygen;
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Current AssigneeOrtho Pharmaceutical Corporation (Johnson & Johnson)
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Original AssigneeOrtho Pharmaceutical Corporation (Johnson & Johnson)
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InventorsDerian, Claudia K., Shank, Richard P.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)CHANNAVAJJALA, LAKSHMI SARADA
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Application NumberUS08/881,010Time in Patent Office344 DaysField of Search549/364, 549/426, 514/456, 514/459, 514/517, 514/863, 514/23, 558/20, 558/48US Class Current514/23CPC Class CodesA61K 31/255 of sulfoxy acids or sulfur ...A61K 31/35 having six-membered rings w...A61K 31/7048 having oxygen as a ring het...
