Extended wear ophthalmic lens
DCFirst Claim
1. An ophthalmic lens having ophthalnically compatible inner and outer surfaces, said lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids, said lens comprising a polymeric material which has a high oxygen permeability and a high ion permeability, said polymeric material being formed from polymerizable materials comprising:
- (a) at least one oxyperm polymerizable material and(b) at least one ionoperm polymerizable material,wherein said lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids,wherein said oxyperm polymerizablea material forms a phase or phases substantially seperate from the phase or phases formed by said ionoperm polymerizable material,wherein said lens allows ion or water permeation via ion or water pathways in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially hared and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids,wherein said ionoperm polyrnerizable material, if polymerized alone would form a hydrophilic polymer having a water content of atleast 10 weight percent upon full hydration, andwherein said ophthalmic lens has an oxygen transmissibility of at least about 70 barrers/mm and an ion permeability characteized either by (1) an Ionoton Ion Permeability Coefficient of greater than about 0.2×
10-6 cm2 /sec. or(2) an Ionoflux Diffusion Coefficient of greater than about 1.5×
1031 6 mm2 /min. wherein said ion permeability is measured with respect to sodium ions.
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Abstract
An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
676 Citations
48 Claims
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1. An ophthalmic lens having ophthalnically compatible inner and outer surfaces, said lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids, said lens comprising a polymeric material which has a high oxygen permeability and a high ion permeability, said polymeric material being formed from polymerizable materials comprising:
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(a) at least one oxyperm polymerizable material and (b) at least one ionoperm polymerizable material, wherein said lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids, wherein said oxyperm polymerizablea material forms a phase or phases substantially seperate from the phase or phases formed by said ionoperm polymerizable material, wherein said lens allows ion or water permeation via ion or water pathways in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially hared and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids, wherein said ionoperm polyrnerizable material, if polymerized alone would form a hydrophilic polymer having a water content of atleast 10 weight percent upon full hydration, and wherein said ophthalmic lens has an oxygen transmissibility of at least about 70 barrers/mm and an ion permeability characteized either by (1) an Ionoton Ion Permeability Coefficient of greater than about 0.2×
10-6 cm2 /sec. or(2) an Ionoflux Diffusion Coefficient of greater than about 1.5×
1031 6 mm2 /min. wherein said ion permeability is measured with respect to sodium ions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. An ophthalmic lens having ophthalmically compatible inner and outer surfaces, said lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids, said lens comprising a polymeric material which has a high oxygen permeability and a high ion permeability, said polymeric material being formed from polymerizable materials comprising at least one polymerizable material comprising:
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(a) at least one oxyperm segment; and (b) at least one ionoperm segment, wherein said lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids, wherein said oxyperm polymerizable mateerial forms a phase or phases substantially separate from the phase of phase formed by said ionoperm polymerizable material, wherein said lens allows ion or water permeation via ion or water pathways in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially harmed and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids, Wherein said ionoperm polymerizable material, if polymerized alone, would form a hydrophilic polymer having a water content of at least 10 weight percent upon full hydration, and Wherein said ophthalmic lens has an oxygen transmissibility of at least about 70 barrers/mm and an ion permeability characterized either by (1) an Ionoton Ion Permeability Coeffecient of greater than about0.2×
1031 6 cm2 /sec. or (2) an Ionoflux Diffusion Coefficient of greater than about 1.5×
10-6 mm2 min. Wherein said ion permeability is measured with respect to sodiumn ions. - View Dependent Claims (45, 46, 47, 48)
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Specification