Anti-infective and anti-inflammatory releasing systems for medical devices

• US 5,762,638 A
• Filed: 02/14/1996
• Issued: 06/09/1998
• Est. Priority Date: 02/27/1991
• Status: Expired due to Term

• Current Assignee: Abraham J. Domb, Alain H. Shikani
• Original Assignee: Abraham J. Domb, Alain H. Shikani
• Inventors: Shikani, Alain H., Domb, Abraham J.
• Primary Examiner(s): Bockelman, Mark
• Assistant Examiner(s): Sadula, Jennifer R.
• Application Number:
  US08/601,251
• Time in Patent Office: 846 Days
• Field of Search: 128/207.14, 128/207.15, 604/890.1, 604/891.1, 604/892.1, 604/264, 604/265, 604/280, 623/1, 623/11, 623/12
• US Class Current: 604/265
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/222 Steroids, e.g. corticosteroids
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0429 with non-integrated distal obturators
• CPC Class Codes: A61M 16/0465 Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
• CPC Class Codes: A61M 16/049 Mouthpieces
• CPC Class Codes: A61M 16/0497 Tube stabilizer
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Medical devices for implantation into the body are coated with anti-infective and or anti-inflammatory agents. The medical devices can be, for example, endotracheal/tracheostomy tubes and catheters. The devices have a polymer coating containing an anti-infective agent and/or an anti-inflammatory agent. The preferred anti-infective agent is iodine and the preferred anti-inflammatory agent is steroidal.

Claims

1. An endoctracheal or tracheostomy tube for implantation into the body and coming into contact with body tissue and fluids comprising said endotracheal or tracheostomy tube having thereon a biocompatible, nonbioerodible polymer dissolved in a solvent to form a solution, the solution being disposed on the exterior surface of the device and the solvent removed to form a uniform coating on the endotracheal or tracheostomy tube thereby coating said exterior surface and wherein said polymer coating is formed of non-hydrogel polymer being insoluble in a biological medium and soluble in an organic solvent, with said polymer coating containing effective amounts of iodine and an antiinflammatory agent sorbed therein, such that the iodine is released over a period of at least twenty-four hours by diffusion while the endotracheal or tracheostomy tube is implanted into the body.