Effusion fluid sucking device

• US 5,762,640 A
• Filed: 05/31/1996
• Issued: 06/09/1998
• Est. Priority Date: 05/31/1995
• Status: Expired due to Fees

• Current Assignee: NEC Corporation
• Original Assignee: NEC Corporation
• Inventors: Fujiwara, Hidetaka, Kajiwara, Yuji
• Primary Examiner(s): Clarke, Robert A.
• Assistant Examiner(s): Cho, David J.
• Application Number:
  US08/655,938
• Time in Patent Office: 739 Days
• Field of Search: 604/289, 604/312-316, 128/632, 128/635, 128/637, 128/760
• US Class Current: 604/313
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/4261 Evaluating exocrine secretion production A61B3/101 takes precedence
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/4881 Determining interstitial fluid distribution or content within body tissue measuring analytes in interstitial fluid in-vivo A61B5/1451

Abstract

A device for sucking an effusion fluid from the skin of an organism from which keratin has been removed. A disk is received in the cavity of a cell for sucking an effusion fluid in contact with the surface of an organism. Guide grooves are formed in the surface of the disk facing a suction port while holes are formed through the disk in each guide groove. The disk allows a minimum of fluid to remain thereon and guides the fluid toward the suction side in order to enhance efficient collection. When the fluid is collected a plurality of times, the preceding fluid and the following fluid are prevented from being mixed together, insuring accurate measurement.

Claims

1. A device for sucking and collecting an effusion fluid from an organism, comprising:

a suction cell comprising a suction port for causing the effusion fluid to effuse from the organism by evacuation, and a cavity formed in an end of said suction cell for directly contacting a surface of the organism;

a first disk received in said cavity and for directly contacting the surface of the organism;

wherein said first disk is formed with a plurality of guide grooves on a surface thereof facing said suction port, and a plurality of through holes in said plurality of guide grooves; and

a second disk interposed between said first disk and said suction port, said second disk covering open ends of said plurality of grooves and formed with a through bore aligned with said suction port.

2. A device as claimed in claim 1, wherein said plurality of grooves extend radially on said first disk.

3. A device as claimed in claim 1, wherein said plurality of grooves comprise radially extending grooves and concentric grooves communicating said radially extending grooves to each other.

4. A device as claimed in claim 1, wherein said first disk further comprises an annular projection at an edge thereof for contacting the surface of the organism to thereby prevent vacuum from decreasing.

5. A device as claimed in claim 1, wherein the metal comprises stainless steel.

6. A device as claimed in claim 1, wherein said first disk has surfaces thereof formed of one of metal and resin sparingly ionizable against the effusion fluid.

7. A device as claimed in claim 6, wherein the metal comprises nickel.

8. A device as claimed in claim 6, wherein the resin comprises polyimide.

9. A device as claimed in claim 6, wherein the resin comprises vinyl chloride.

10. A device as claimed in claim 1, wherein said through holes and said guide grooves have a total capacity of about 10 μ

l.

11. A device for sucking and collecting a liquid effused from a surface of a multicellular organism comprising:

a suction cell having a suction port;

a cavity in an end of said suction cell, said cavity in communication with said suction port;

a disk with at least one guide groove on a suction cell side of said disk, whereby said guide groove for guiding said liquid effused from said surface of said multicellular organism through at least a portion of said cavity;

a plurality of through-holes through said disk, said through-holes providing communication between said suction cell side of said disk to an opposite side; and

a cover disk on said suction cell side of said disk with at least one guide groove, said cover disk having a lumen in communication with said suction port said cover disk providing a cover on said at least one guide groove.

12. The device according to claim 11, wherein said disk has a thickness of about 0.1 mm.

13. The device according to claim 11, wherein said disk has a diameter of about 30 mm.

14. The device according to claim 11, wherein said at least one guide groove has a width of about 0.15 mm.

15. The device according to claim 11, wherein said at least one guide groove has a depth of about 0.05 mm.

16. The device according to claim 11, wherein said at least one guide groove has a length less than about 15 mm.

17. The device according to claim 11, wherein said at least one guide groove comprises a plurality of guide grooves in a radial pattern.

18. The device according to claim 11, wherein said at least one guide groove comprises at least one annular groove.

19. The device according to claim 11, wherein said through-holes have a diameter of about 0.1 mm.

20. The device according to claim 11, wherein said at least one guide groove is formed by etching.

21. The device according to claim 20, wherein said etching comprises photolithography.

22. The device according to claim 11, further comprising a biosensor for measuring a concentration of a chemical substance in said liquid effused.

23. The device according to claim 22, wherein said chemical substance is glucose.

24. The device according to claim 11, wherein said disk includes at least one annular projection on said opposite side.

25. The device according to claim 11, further comprising a collection chamber.

26. The device according to claim 11, further comprising an O-ring sealing between said suction port and said disk.

27. The device according to claim 11, further comprising an O-ring sealing between said suction port and said disk.

28. The device according to claim 11, wherein said disk comprises irregular grooves on said opposite side, said irregular grooves providing a surface roughness of several microns.