Modified recombinant vaccinia virus and expression vectors thereof
First Claim
1. A recombinant vaccinia virus wherein regions C7L-K3L, J2R, B13R+B14R, A26L, A56R and I4L have been deleted therefrom.
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Abstract
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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Citations
11 Claims
- 1. A recombinant vaccinia virus wherein regions C7L-K3L, J2R, B13R+B14R, A26L, A56R and I4L have been deleted therefrom.
- 2. A recombinant vaccinia virus wherein regions C23L-F4L, J2R, B13R+B14R, A26L, A56R and I4L have been deleted therefrom.
- 3. A recombinant vaccinia virus wherein regions C7L-K1L, J2R, B13R-B29R, A26L, A56R and I4L have been deleted therefrom.
- 4. A recombinant vaccinia wherein regions C23L-F4L, J2R, B13R-B29R, A26L, A56 and I4L have been deleted therefrom.
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9. A recombinant vaccinia virus selected from the group consisting of:
- vP954, vP938, vP953, vP977, vP996, vP1006 and vP1015.
Specification