Moist bacteriocin disinfectant wipes and methods of using the same

• US 5,762,948 A
• Filed: 06/07/1995
• Issued: 06/09/1998
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Ambi, Inc. (NXXI, Inc.)
• Original Assignee: Ambi, Inc. (NXXI, Inc.)
• Inventors: Blackburn, Peter, de la Harpe, Jon
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Shelborne, Kathryne E.
• Application Number:
  US08/479,280
• Time in Patent Office: 1,098 Days
• Field of Search: 424/118, 424/120, 424/121, 424/404, 424/402, 514/2, 514/12
• US Class Current: 424/404
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/22 containing ingredients stabilising the active ingredients
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/46 N-acyl derivatives
• CPC Class Codes: A01N 59/08 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A01N 63/50 Isolated enzymes; Isolated proteins peptides A01N37/46

Abstract

Disclosed are novel, moist paper or fabric wipes containing a bacteriocin disinfectant formulation, which have a low alcohol content and which afford rapid, one-step disinfection and drying of surfaces. Also disclosed is a method of disinfection and drying of skin, including cow teat skin, either prior to or after milking, which employs the wipes.

Claims

1. A moist paper or fabric wipe containing a liquid formulation comprising a suitable amount of a bacteriocin, a chelating agent, a stabilizer, a surfactant, a salt and an alcohol drying agent.

2. A wipe according to claim 1 wherein the bacteriocin is a lanthocin;

the chelating agent is selected from one or more of an alkydiamine tetraacetate, EGTA and citrate;

the stabilizer is a thioether compound;

the surfactant is a nonionic surfactant, a cationic surfactant, a monoglyceride or a fatty acid; and

the salt is NaCl.

3. A wipe according to claim 2 wherein the lanthocin is nisin, the chelating agent is EDTA, the stabilizer is methionine, the surfactant is polysorbate 20 and the drying agent is 1-propanol.

4. A wipe according to claim 3, wherein the chelating agent comprises EDTA and citrate in combination.

5. A wipe according to claim 3 wherein the concentration of nisin is in the range of 25 to 500 ug/ml and the concentration of NaCl is in the range of 10 to 300 mM.

6. A wipe according to claim 3 wherein the concentration of EDTA is in the range of 0.1 to 10 mM.

7. A wipe according to claim 4 wherein the concentration of EDTA is in the range of 0.1 to 10 mM and the concentration of citrate is in the range of 1 to 30 mM.

8. A wipe according to claim 3 wherein the concentration of methionine is in the range of 1 to 10 mM.

9. A wipe according to claim 3 wherein the concentration of polysorbate 20 is in the range of 0.1 to 3%.

10. A wipe according to claim 3 wherein the concentration of 1-propanol is in the range of 10 to 20%.

11. A wipe according to claim 1 wherein the formulation further comprises a conditioner and a thickener.

12. A wipe according to any one of claims 1-4, wherein the formulation further comprises chlorhexidine.

13. A wipe according to any one of claims 1-4 wherein the paper wipe is of a non-woven material.

14. A one-step method for disinfecting and drying a cow teat prior to milking which comprises wiping the teat with a wipe according to any one of claims 1-4.

15. A one-step method for disinfecting and drying a cow teat after milking which comprises wiping the teat with a wipe according to any one of claims 1-4.

16. A one-step method for disinfecting and drying a skin surface which comprises wiping the skin surface with a wipe according to any one of claims 1-4.

17. A one-step method for cleansing a skin surface which comprises wiping the skin surface with a wipe according to any one of claims 1-4.

18. A one-step method for disinfecting and drying a food contact surface which comprises wiping the food contact surface with a wipe according to any one of claims 1-4.

19. A method for reducing the incidence of mastitis infection in dairy animals, which comprises wiping the animals'"'"' teats after milking with a wipe according to any one of claims 1-4.

20. A method for reducing the incidence of mastitis infection in dairy animals, which comprises pre-milking wiping of the animals'"'"' teats with a wipe according to any one of claims 1-4 in conjunction with post-dipping with Consept teat dip.