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Method of phosphate ester hydrolysis

  • US 5,763,172 A
  • Filed: 06/07/1995
  • Issued: 06/09/1998
  • Est. Priority Date: 01/21/1992
  • Status: Expired due to Fees
First Claim
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1. A method for enhancing the therapeutic activity of an oligonucleotide in a cell, the method comprising:

  • contacting a targeted intracellular RNA in a cell with a metallotexaphyrin-oligonucleotide conjugate, the contact being under physiologic conditions and for a time sufficient to hydrolyze the phosphate ester bond of said targeted intracellular RNA, wherein the metallotexaphyrin of said metallotexaphyrin-oligonucleotide conjugate has catalytic activity for phosphate ester bond hydrolysis and the oligonucleotide of said metallotexaphyrin-oligonucleotide conjugate has complementary binding affinity to said targeted intracellular RNA.

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