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Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures

  • US 5,763,267 A
  • Filed: 04/16/1996
  • Issued: 06/09/1998
  • Est. Priority Date: 04/16/1996
  • Status: Expired due to Term
First Claim
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1. An apparatus, comprisinga plurality of growth chambers comprising flexible front and back sheets bonded together along predetermined boundaries to delimit a first port for the inflow of fluid into said growth chambers, a second port for the outflow of fluid from said growth chambers, and at least one compartment for growth of tissue;

  • at least one substrate disposed within each of said plurality of growth chambers designed to facilitate three-dimensional tissue growth on said substrate;

    a plurality of spacer members adapted to contact the flexible growth chambers in a manner which maintains even fluid distribution within the chambers, thereby promoting even growth of tissue;

    an inlet manifold with an inlet port and a plurality of outlet ports for uniformly providing fluid to the growth chambers, said outlet ports adapted to mate with the first ports of the growth chambers;

    an outlet manifold with a plurality of inlet ports, each of said inlet ports adapted to mate with the second ports of the growth chambers; and

    a support member for connecting said plurality of spacer members to said inlet and outlet manifolds.

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