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2-acylaminopropanol compound and medical composition

  • US 5,763,438 A
  • Filed: 12/09/1996
  • Issued: 06/09/1998
  • Est. Priority Date: 06/10/1994
  • Status: Expired due to Term
First Claim
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1. A 2-acylaminopropanol compound of the formula ##STR17## wherein R1 is phenyl optionally substituted by 1 to 3 members selected from the group consisting of alkyl, alkoxy, hydroxyl, hydroxyalkyl and nitro, R2 is a formula selected from the group consisting of ##STR18## wherein R3 and R4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, cycloalkyl, hydroxycycloalkyl, aralkyl and piperazino optionally substituted by alkyl, R5 is 1 or 2 substituents selected from the group consisting of hydrogen, hydroxyl, lower alkyl, alkoxy, hydroxyalkyl, carboxy, alkoxycarbonyl, aralkyl, piperidino, acyloxy, of an organic carboxylic acid amino and aminoalkyl, R6 is hydrogen or 1 or 2 substituents of R5, R7 is alkylene optionally interrupted by oxygen, R8 and R9 are individually selected from the group consisting of hydrogen, lower alkyl and hydroxy-lower alkyl, or R8 and R9 together with the nitrogen atom to which they are bonded form a piperidino or morpholino optionally substituted by lower alkyl, m is an integer of 2 to 6, p is 2 or 3, X is ##STR19## wherein R10 is selected from the group consisting of hydrogen, lower alkyl, acyl, lower alkoxycarbonyl and pyridyl, R11 is hydrogen or hydroxyl and n is an integer of 3 to 15) or a non-toxic, pharmaceutically acceptable salt thereof.

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