Lymphocyte activation antigens and antibodies thereto

• US 5,766,570 A
• Filed: 04/24/1995
• Issued: 06/16/1998
• Est. Priority Date: 04/17/1992
• Status: Expired due to Term

• Current Assignee: Dana-Farber Cancer Institute
• Original Assignee: Dana-Farber Cancer Institute
• Inventors: Zhou, Liang-Ji, Tedder, Thomas F.
• Primary Examiner(s): Hutzell, Paula K.
• Assistant Examiner(s): BAKALYAR, HEATHER
• Application Number:
  US08/428,943
• Time in Patent Office: 1,149 Days
• Field of Search: 530/387.1, 530/387.3, 530/388.1, 530/388.22, 530/391.3, 435/240.27, 424/1.49
• US Class Current: 424/1.49
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/70503 Immunoglobulin superfamily
• CPC Class Codes: C07K 16/2803 against the immunoglobulin superfamily

Abstract

HB15-related lymphocyte activation antigens, and nucleic acid sequences encoding HB15-related antigens are disclosed. Also disclosed are antibodies reactive with HB15.

Claims

1. An antibody that specifically recognizes a polypeptide having the sequence of the extracellular domain, the transmembrane domain, or the cytoplasmic domain of the HB15 protein having the amino acid sequence given in SEQ ID NO:

2.

2. A monoclonal antibody that specifically recognizes the HB15 protein having the amino acid sequence given in SEQ ID NO:

2.

3. The monoclonal antibody of claim 2, said antibody being produced by the hybridoma cell line deposited as ATCC No. HB 10987, said antibody being denominated anti-HB15a.

4. The monoclonal antibody of claim 2, said antibody being produced by the hybridoma cell line deposited as ATCC No. HB 10988, said antibody being denominated anti-HB15b.

5. The hybridoma cell line deposited as ATCC No. HB 10987.

6. The hybridoma cell line deposited as ATCC No. HB 10988.

7. An imaging agent for imaging a site of HB15 expression in a human patient comprising a monoclonal antibody that specifically recognizes the HB15 protein having the amino acid sequence given in SEQ ID NO:

2, said monoclonal antibody being labeled with a detectable label suitable for immunoimaging.

8. An antibody that specifically recognizes an immunogenic polypeptide fragment having a sequence of a portion of the amino acid sequence disclosed in SEQ ID NO:

2.