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Liposomal defensins

  • US 5,766,624 A
  • Filed: 05/24/1995
  • Issued: 06/16/1998
  • Est. Priority Date: 10/25/1993
  • Status: Expired due to Fees
First Claim
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1. A method of treating a mammal for an infection by a microbe sensitive to a defensin, the method comprising administering to the mammal a liposome comprising:

  • (a) a bilayer comprising a lipid which comprises palmitoyloleoyl phosphatidylcholine, dioleoyl phosphatidylcholine or distearoyl phosphatidylcholine and cholesterol;

    (b) an internal compartment comprising an aqueous buffer; and

    ,(c) a neutralized defensin selected from the group consisting of prototypical mammalian defensins, beta-defensins, indolicidin, magainins and insect defensins,wherein an amount of the liposome comprising an anti-infection effective amount of the defensin is administered.

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