Lubricating and/or germicidal composition

• US 5,767,163 A
• Filed: 02/16/1996
• Issued: 06/16/1998
• Est. Priority Date: 02/22/1994
• Status: Expired due to Fees

• Current Assignee: Kundsin Leduc Lenmark Incorporated
• Original Assignee: Kundsin Leduc Lenmark Incorporated
• Inventors: Kundsin, Ruth B.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US08/602,581
• Time in Patent Office: 851 Days
• Field of Search: 514/557, 514/558, 514/642, 514/724, 514/844, 514/846, 514/847, 514/873
• US Class Current: 514/642
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention is directed to a lubricating and/or germicidal composition, and a method of using the composition as an antiseptic for the hands or as a disinfectant for other inanimate objects, and/or for alleviating or preventing drying of skin. The composition is an alcoholic solution containing cetyl alcohol, glycolic acid, benzalkonium chloride, and a major amount of isopropyl alcohol. In a preferred use, the composition is applied to the surface of the hands as an antiseptic film or "invisible glove" beneath a surgical or other plastic glove to inhibit microbial growth and alleviate drying of the skin.

Claims

1. A composition, comprising:

(a) about 1-25 wt-% cetyl alcohol;

(b) an effective lubricating amount of glycolic acid;

(c) an effective bactericidal amount of benzalkonium chloride; and

(d) a major amount of isopropyl alcohol;

the combination of isopropyl alcohol, glycolic acid and benzalkonium chloride being germicidally effective.

2. The composition according to claim 1, comprising about 1-10 wt-% cetyl alcohol.

3. The composition according to claim 1, comprising about 0.1-3 wt-% glycolic acid.

4. The composition according to claim 3, comprising about 0.2-0.3 wt-% glycolic acid.

5. The composition according to claim 1, comprising about 60-98% isopropyl alcohol.

6. The composition according to claim 1, comprising about 90-98% isopropyl alcohol.

7. The composition according to claim 1, comprising about 0.1-1.5 wt-% benzalkonium chloride.

8. The composition according to claim 7, comprising about 0.1-0.5 wt-%, benzalkonium chloride.

9. The composition according to claim 1, wherein the composition is effective in inhibiting the growth of a microorganism selected from the group consisting of gram-positive bacteria, gram-negative bacteria, fungi, viruses, alga, and any combination thereof.

10. The composition according to claim 1, wherein the composition is effective in alleviating or preventing drying of the skin.

11. The composition according to claim 10, wherein the composition is effective against a bacteria selected from the group consisting of Staphylococcus aureus, Staphylococcus epidermidis, Salmonella cholerasuis, Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes, Enterobacter agglomerans, Serratia marcescens, Legionella pneumophila, Listeria monocytogenes, Leucothrix mucor, Mycobacterium tuberculosis, and any combination thereof.

12. The composition according to claim 11, wherein the composition is effective against a fungus selected from the group consisting of Candida albicans, Trichophyton mentagrophytes, Aspergillus niger, Myrathecium verrucaria, Trichoderma viride, and Chaetomium globosum, and any combination thereof.

13. The composition according to claim 11, wherein the composition is effective against an alga selected from the group consisting of Stigeoclonium spp., Oscillaturia tenuis, any Anacystis cylindrica.

14. The composition according to claim 11, wherein the composition is effective against a virus selected from the group consisting of rhinovirus, parainfluenza virus, adenovirus, rabies, human immunodeficiency virus, Coxsackie virus, echo virus, poliovirus, herpes simplex, vaccinia virus, influenza virus, and any combination thereof.

15. The composition according to claim 11, wherein the composition is effective against Entamoeba hystolytica.

16. The composition according to claim 1, comprising:

(a) about 1-25 wt-% cetyl alcohol;

(b) about 0.1-3 wt-% glycolic acid;

(c) about 0.1-1.5 wt-% of benzalkonium chloride; and

(d) about 60-98 wt-% isopropyl alcohol.

17. A method of disinfecting skin, comprising:

contacting the skin with the composition of claim 1.

18. The method according to claim 17, wherein the method further comprises:

allowing the composition to dry to a film on the skin; and

maintaining the composition on the skin for a time effective to deliver a germicidal effect to the skin.

19. The method according to claim 17, wherein the substrate is the skin of a hand, and the method further comprises applying a glove onto the hand over the composition.

20. A method of lubricating and inhibiting drying of skin, comprising:

contacting the skin with the composition of claim 1.

21. The method according to claim 20, further comprising:

allowing the composition to dry to a film on the skin; and

maintaining the composition on the skin for a time effective to deliver a lubicating effect to the skin.

22. An article of manufacture comprising the composition of claim 1 packaged within containing means, and instruction means for using the composition for inhibiting the growth of a microorganism on human skin or an inanimate object, or for lubricating the skin to inhibit drying, or a combination thereof.

23. The article according to claim 22, wherein the containing means is selected from the group consisting of a vial, jar, pouch, absorbent fibrous sheet, or any combination thereof.

24. The article according to claim 23, wherein the containing means comprises means for spraying.

25. The article according to claim 22, wherein the instructions means is a label or tag attached to the packaging, a printed package insert, or a combination thereof.

26. The article according to claim 22, further comprising a plastic glove, a material for applying the composition to a substrate, or a combination thereof.