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Method of manufacturing natural tissue valves having variably compliant leaflets

  • US 5,769,780 A
  • Filed: 10/09/1997
  • Issued: 06/23/1998
  • Est. Priority Date: 09/02/1994
  • Status: Expired due to Term
First Claim
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1. A process for fixing a natural tissue valve prosthesis having improved hemodynamic characteristics and resistance to calcification, said process comprising:

  • (a) obtaining a mammalian natural tissue valve assembly having a circumferential annular margin and one or more valve leaflets pivotally attached to said circumferential annular margin, each of said one or more valve leaflets including a leaflet base section adjacent to said circumferential annular margin and a leaflet tip section disposed radially therefrom;

    (b) subjecting each of said leaflet base sections of said one or more valve leaflets to a higher pressure than each of said leaflet tip sections on the same side of the valve leaflet; and

    (c) contacting each of said sections of said pressurized natural tissue valve assembly with a fixing agent.

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