Apparatus for controlled delivery of liquids

• US 5,769,824 A
• Filed: 03/26/1993
• Issued: 06/23/1998
• Est. Priority Date: 07/26/1990
• Status: Expired due to Fees

• Current Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Original Assignee: Pharmacia & Upjohn AB (Pharmacia Corp.)
• Inventors: Michel, Peter, Hjertman, Birger
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): Sadula, Jennifer R.
• Application Number:
  US08/500,383
• Time in Patent Office: 1,915 Days
• Field of Search: 604/81-5, 604/89-91, 604/131, 604/140-1, 604/143, 604/146-7, 604/149, 604/152, 604/181-3, 604/187, 604/218, 604/221, 604/228, 604/233-4, 604/246, 604/249 , 604/256, 222/386, 222/389
• US Class Current: 604/143
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate

Abstract

An apparatus for controlled delivery of a liquid consists of a delivery unit which comprises a liquid container (3) having at least one movable wall (12) and a liquid outlet which is provided with a flow restriction, and a power unit which comprises a second container (21) which also has at least one movable wall (29) and wherein a vacuum may be established, and a mechanical coupling (31) between the movable wall (12) of the liquid container(3) and the movable wall (29) of the second container (21). The delivery unit and the power unit are connected together coaxially when the apparatus is prepared for delivery, and in this connecting together, the movable wall (29) of the second container is displaced by means of the mechanical coupling (31) such that the vacuum is established. The ambient atmospheric pressure then acts against this vacuum, and this pressure is transmitted by the mechanical coupling (31), which is directly acting on the movable wall (12) of the liquid container (3) such that the liquid is forced out through the outlet (4) and the restriction therein.

Claims

1. An apparatus for the controlled delivery of a liquid having a delivery unit comprising a first liquid container having at least one movable wall and a liquid outlet;

wherein said movable wall is connected to a mechanical coupling; and

a power unit which comprises a second container having a front end, a rear end, at least one movable wall wherein a vacuum can be established, and a sleeve having a front end and a rear end wherein said sleeve is joined at its front end to said delivery unit and at its rear end is joined to said movable wall of the power unit, which movable wall is slidably mounted in said second container;

wherein said second container is connected to said mechanical coupling;

said second container being closed at its rear end and defining a closed space and wherein its front end provides access for the ambient atmosphere; and

wherein said delivery unit and said power unit are connected together coaxially.

2. The apparatus of claim 1, characterized in that the container for the liquid constitutes a syringe for injection or infusion.

3. The apparatus of claim 2, characterized in that the syringe comprises a sleeve holding a cartridge for injection.

4. The apparatus of claim 3, characterized in that the cartridge has two chambers which are separated by a movable wall, and a bypass channel between the two chambers, said bypass channel becoming operative by the movement of said movable wall of said cartridge.

5. The apparatus of claim 1, wherein said liquid outlet is provided with a flow restriction.

6. The apparatus of claim 5, characterized in that the flow restriction is arranged as a constriction in the flow path of the liquid.

7. The apparatus of claim 5, characterized in that the restriction is variable.

8. The apparatus of claim 1, characterized in that the movable walls in the containers are pistons or plungers.

9. The apparatus of claim 1, characterized in that one or both of the movable walls is a membrane.

10. An apparatus for the controlled delivery of a liquid having a delivery unit comprising a first liquid container having at least one movable wall and a liquid outlet;

wherein said movable wall is connected to a mechanical coupling; and

a power unit which comprises a second container having a front end, a rear end, at least one movable wall wherein a vacuum can be established;

wherein the movable wall of said power unit is connected to said mechanical coupling or wherein said power unit further comprises a sleeve having a front end and a rear end wherein said sleeve is joined at its front end to said delivery unit and at its rear end is joined to said movable wall of the power unit and said second container is connected to said mechanical coupling; and

wherein said liquid container is a syringe for injection or infusion which comprises a front sleeve and a rear sleeve which are axially movable relative to each other for holding a cartridge that has a rear chamber and a front chamber which are separated by a movable wall, and a bypass channel between the rear and front chambers, said bypass channel becoming operative by the movement of said wall;

of said cartridge and wherein a first piston is contained in said rear chamber and a second piston is contained in said front chamber; and

a third piston is contained within said second container; and

wherein said second container also includes limiting means for preventing said third piston from moving towards said second container until said first piston is in a position of resting against said second piston; and

wherein said delivery unit and said power unit are connected together coaxially.

11. The apparatus of claim 10 wherein said liquid outlet is provided with a flow restriction.

12. The apparatus of claim 11, characterized in that the flow restriction is arranged as a constriction in the flow path of the liquid.

13. The apparatus of claim 11, characterized in that the restriction is variable.

14. The apparatus of claim 10 wherein said movable wall of said power unit is connected to said mechanical coupling.

15. The apparatus of claim 14 characterized in that the movable walls in the containers are pistons or plungers, and that the mechanical coupling is a piston rod, which connects the two pistons or plungers.

16. The apparatus of claim 10 wherein said limiting means is a distance rod.

17. The apparatus of claim 14 characterized in that one or both of the movable walls is a membrane.