Biodegradable drug delivery vascular stent

• US 5,769,883 A
• Filed: 11/21/1995
• Issued: 06/23/1998
• Est. Priority Date: 10/04/1991
• Status: Expired due to Term

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Wang, Lixiao, Buscemi, Paul J., Stejskal, Elizabeth A., Palme, Donald F. II
• Primary Examiner(s): Brittingham, Debra S.
• Application Number:
  US08/561,374
• Time in Patent Office: 945 Days
• Field of Search: 623/1, 623/11, 623/12, 600/36, 606/194, 606/195, 606/198
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0023 operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/047 Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

Claims

1. A stent having a generally tubular main body for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material composed of polylactic acid in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs and said tubular main body being expandable within a lumen of a vessel of a living being.

2. The stent of claim 1 wherein the strengthening material includes particles dispersed within the biodegradable matrix.

3. The stent of claim 1 wherein the strengthening material includes a layer attached to the matrix.

4. The stent of claim 1 wherein the biodegradable matrix further includes a glycosaminoglucuronan.

5. The stent of claim 4 wherein the glycosaminoglucuronan includes heparin.

6. A stent having a generally tubular main body for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs, wherein the drugs include microencapsulated drugs.