Controlled porosity endovascular implant

• US 5,769,884 A
• Filed: 06/27/1996
• Issued: 06/23/1998
• Est. Priority Date: 06/27/1996
• Status: Expired due to Term

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Solovay, Kenneth S.
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): Black, John M.
• Application Number:
  US08/671,387
• Time in Patent Office: 726 Days
• Field of Search: 623/1, 623/16, 606/190-200
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

A covered stent for treating a stenotic region in a blood vessel. The stent covering has different porosities in different regions. In those regions, typically the ends, where tissue ingrowth and re-endothelialization are desired, the stent covering is more porous, and in those regions were it is desirable to inhibit such ingrowth, the stent covering is substantially non-porous.

Claims

1. An endoprosthesis implant comprising:

a) a stent having an expandable frame structure;

b) a stent covering disposed on said stent, said stent covering having opposed ends, a first region of the stent covering comprising portions of the stent covering adjacent the opposed ends and a second region of the stent covering comprising a middle portion of the stent covering interposed between the first region portions;

c) the first region having a plurality of pores extending between an inner surface and a spaced apart outer surface of the stent covering defining a first porosity, and the second region having a second porosity different than said first porosity, said second porosity being defined by said second region having fewer pores than said first region; and

d) each pore in the first region having a pore diameter at the stent covering outer surface of from about 30 to about 120 micrometers.

2. The endoprosthesis implant according to claim 1 wherein an average distance between adjacent pores in the first region being at least about 3 times an average pore diameter of the pores in the first region.

3. The endoprosthesis implant according to claim 1 wherein the stent covering is substantially cylindrical.

4. The endoprosthesis implant according to claim 1 wherein said second region has a plurality of pores each having a pore diameter at the stent covering outer surface that is smaller than 30 micrometers.

5. The endoprosthesis implant according to claim 1 wherein said second region has substantially no pores.

6. The endoprosthesis implant according to claim 1 wherein said second region is substantially impermeable to passage of body fluids under atmospheric pressure.

7. The endoprosthesis implant according to claim 1 wherein said stent covering comprises a plurality of fibers, said fibers having an average diameter that is larger than an average pore diameter of said pores in said first region.

8. The endoprosthesis implant according to claim 7 wherein said fibers have an average diameter of at least about three times said average pore diameter of the pores in the first region.

9. The endoprosthesis implant according to claim 1 wherein said pores in said first region have a shortest pore width of not less than about 30 micrometers and not greater than about 120 micrometers.

10. The endoprosthesis implant according to claim 7 wherein said fibers are woven.

11. The endoprosthesis implant according to claim 7 wherein said fibers are braided.

12. The endoprosthesis implant according to claim 7 wherein said fibers are knitted.

13. The endoprosthesis implant according to claim 1 wherein said stent covering comprises a substantially continuous polymeric sheet having pores interspersed in at least said first region, said pores having an average pore diameter and being spaced apart an average distance that is greater than said average pore diameter.

14. The endoprosthesis implant according to claim 13 wherein said pores are spaced apart an average distance of at least about 3 times said average pore diameter.

15. The endoprosthesis implant according to claim 13 wherein said pores are disposed only in said first region.

16. The endoprosthesis implant according to claim 13 wherein said second region is substantially impermeable to passage of body fluids under atmospheric pressure.

17. The endoprosthesis implant according to claim 13 wherein said pores have a shortest pore width of not less than about 30 micrometers and not greater than about 120 micrometers.

18. The endoprosthesis implant according to claim 1 wherein said pores in said first region have an average pore diameter and are spaced apart an average distance that is greater than said average pore diameter.

19. An endoprosthesis implant comprising:

a) a stent having an expandable frame structure;

b) a stent covering disposed on said stent, said stent covering including a first region having a structure adapted to promote tissue ingrowth, and a second region having a structure adapted to inhibit tissue ingrowth;

c) the first region having a plurality of pores extending between an inner surface and a spaced apart outer surface of the stent covering defining a first porosity and the second region having a second porosity different than the first porosity, each pore in the first region having a pore diameter at the stent covering outer surface of from about 30 to about 120 micrometers; and

d) an average distance between adjacent pores in the first region being at least about 3 times an average pore diameter of the pores in the first region.

20. The endoprosthesis implant according to claim 19 wherein said stent covering is substantially cylindrical and has opposed ends, and said first region comprises portions of said stent covering adjacent said opposed ends, and said second region comprises a middle portion of said stent covering interposed between said first region portions.

21. The endoprosthesis implant according to claim 19 wherein said stent covering comprises a substantially continuous polymeric sheet having voids interspersed therein in at least said first region, said voids in said first region having an average diameter and being spaced apart a distance effective to promote tissue ingrowth into said stent covering in said first region, said second region having no voids, or voids having a diameter and spacing effective to inhibit tissue ingrowth h into said stent covering in said second region.

22. The endoprosthesis implant according to claim 21 wherein said average diameter of said voids in said first region is from about 30 to about 120 micrometers, and said voids in said first region are spaced apart an average distance of at least about 3 times said diameter of said voids in said first region.

23. The endoprosthesis implant according to claim 21 wherein said stent covering is substantially cylindrical and has opposed ends, and said first region comprises portions of said stent covering adjacent said opposed ends, and said second region comprises a middle portion of said stent covering interposed between said first region portions.