Device for packing chromatographic stationary phases
First Claim
1. A chromatography column, comprising:
- a column;
a stationary phase packed in said column, said stationary phase including rolled cellulosic fabric radially compressed within said column and exhibiting a packing density of at least about 0.5 g/cc;
said chromatography column being characterized by its preparation by a process including passing the rolled cellulosic fabric through a funnel member having converging walls so as to radially compress the rolled cellulosic fabric as it enters said column;
said chromatography column further having a void fraction of less than about 0.4 as measured by bovine serum albumin.
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Abstract
Devices and methods for packing a chromatography column with a continuous stationary phase. The preferred device includes a brace member with an engagement surface. The brace member defines a thru-hole at a location so that a passageway defined through the column is aligned with the thru-hole of the brace member when a first end of the column is engaged with the engagement surface of the brace member. A funnel member engageable with an end of the column opposite the first end. The funnel member has converging walls configured to radially compress the continuous stationary phase for entry into the passageway of the column when the continuous stationary phase is pulled through the funnel member. The device includes a mechanism for applying mechanical force to pull the rolled continuous stationary phase through the funnel member wherein the stationary phase is radially compressed and enters the passageway of the column.
15 Citations
4 Claims
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1. A chromatography column, comprising:
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a column; a stationary phase packed in said column, said stationary phase including rolled cellulosic fabric radially compressed within said column and exhibiting a packing density of at least about 0.5 g/cc; said chromatography column being characterized by its preparation by a process including passing the rolled cellulosic fabric through a funnel member having converging walls so as to radially compress the rolled cellulosic fabric as it enters said column; said chromatography column further having a void fraction of less than about 0.4 as measured by bovine serum albumin. - View Dependent Claims (2, 3, 4)
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Specification
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- Resources
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Current AssigneePurdue Research Foundation (Purdue University)
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Original AssigneePurdue Research Foundation (Purdue University)
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InventorsBrewer, Mark, Ladisch, Michael, Hendrickson, Richard, Hamaker, Kent
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Primary Examiner(s)Therkorn, Ernest G.
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Application NumberUS08/755,135Time in Patent Office578 DaysField of Search210/635, 210/656, 210/198.2, 210/494.1, 210/232, 210/236, 210/237, 210/238, 210/249, 210/541, 95/82, 95/88, 96/101, 96/149US Class Current210/198.2CPC Class CodesB01D 15/206 Packing or coatingG01N 2030/562 packingG01N 30/56 Packing methods or coating ...
