Therapeutic drug delivery systems
First Claim
1. A targeted therapeutic delivery system comprising a gas-filled lipid-containing microsphere wherein said gas-filled microsphere has an interior volume of at least about 50% gas, and comprises a therapeutic compound wherein said therapeutic compound is selected from the group consisting of antineoplastic agents;
- blood products;
biological response modifiers;
anti-fungal agents;
hormones;
vitamins;
peptides;
anti-tuberculars;
enzymes;
anti-allergic agents;
anti-coagulation agents;
circulatory drugs;
metabolic potentiators;
antivirals;
antianginals;
antibiotics;
antiinflammatories;
antiprotozoans;
antirheumatics;
narcotics;
opiates;
cardiac glycosides;
neuromuscular blockers;
sedatives;
local anesthetics;
general anesthetics;
radioactive compounds;
monoclonal antibody;
genetic material;
prodrugs; and
combinations thereof.
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Accused Products
Abstract
Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
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Citations
75 Claims
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1. A targeted therapeutic delivery system comprising a gas-filled lipid-containing microsphere wherein said gas-filled microsphere has an interior volume of at least about 50% gas, and comprises a therapeutic compound wherein said therapeutic compound is selected from the group consisting of antineoplastic agents;
- blood products;
biological response modifiers;
anti-fungal agents;
hormones;
vitamins;
peptides;
anti-tuberculars;
enzymes;
anti-allergic agents;
anti-coagulation agents;
circulatory drugs;
metabolic potentiators;
antivirals;
antianginals;
antibiotics;
antiinflammatories;
antiprotozoans;
antirheumatics;
narcotics;
opiates;
cardiac glycosides;
neuromuscular blockers;
sedatives;
local anesthetics;
general anesthetics;
radioactive compounds;
monoclonal antibody;
genetic material;
prodrugs; and
combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 40, 41, 45, 47, 51, 55, 56, 57, 58, 59, 60, 61, 65, 69, 70, 71, 72, 73)
- blood products;
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19. A drug delivery system comprising a gas-filled liposome prepared by a vacuum drying gas instillation method and having encapsulated therein a drug, wherein said gas-filled liposome has an interior volume of at least about 50% gas, and wherein said drug is selected from the group consisting of antineoplastic agents;
- blood products;
biological response modifiers;
anti-fungal agents;
hormones;
vitamins;
peptides;
anti-tuberculars;
enzymes;
anti-allergic agents;
anti-coagulation agents;
circulatory drugs;
metabolic potentiators;
antivirals;
antianginals;
antibiotics;
antiinflammatories;
antiprotozoans;
antirheumatics;
narcotics;
opiates;
cardiac glycosides;
neuromuscular blockers;
sedatives;
local anesthetics;
general anesthetics;
radioactive compounds;
monoclonal antibody;
genetic material;
prodrugs and combinations thereof. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 42, 43, 44, 46, 48, 52, 62, 66)
- blood products;
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29. A drug delivery system comprising a gas-filled liposome wherein said gas-filled liposome has an interior volume of at least about 50% gas and comprises a drug encapsulated therein, wherein said drug is selected from the group consisting of antineoplastic agents;
- blood products;
biological response modifiers;
anti-fungal agents;
hormones;
vitamins;
peptides;
anti-tuberculars;
enzymes;
anti-allergic agents;
anti-coagulation agents;
circulatory drugs;
metabolic potentiators;
antivirals;
antianginals;
antibiotics;
antiinflammatories;
antiprotozoans;
antirheumatics;
narcotics;
opiates;
cardiac glycosides;
neuromuscular blockers;
sedatives;
local anesthetics;
general anesthetics;
radioactive compounds;
monoclonal antibody;
genetic material;
prodrugs; and
combinations thereof. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 49, 53, 63, 67, 74)
- blood products;
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39. A drug delivery system prepared by a method comprising the steps of:
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(i) placing under negative pressure liposomes having encapsulated therein a drug, wherein said drug is selected from the group consisting of antineoplastic agents;
blood products;
biological response modifiers;
anti-fungal agents;
hormones;
vitamins;
peptides;
anti-tuberculars;
enzymes;
anti-allergic agents;
anti-coagulation agents;
circulatory drugs;
metabolic potentiators;
antivirals;
antianginals;
antibiotics;
antiinflammatories;
antiprotozoans;
antirheumatics;
narcotics;
opiates;
cardiac glycosides;
neuromuscular blockers;
sedatives;
local anesthetics;
general anesthetics;
radioactive compounds;
monoclonal antibody;
genetic material;
prodrugs; and
combinations thereof;(ii) incubating said liposomes under the negative pressure for a time sufficient to remove substantially all liquid from said liposomes; and (iii) instilling gas into said liposomes until ambient pressures are achieved to produce a drug delivery system comprising gas-filled liposomes having an interior volume of at least about 50% gas. - View Dependent Claims (50, 54, 64, 68, 75)
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Specification