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Ophthalmic preparation for use as artificial tear

  • US 5,770,628 A
  • Filed: 07/21/1995
  • Issued: 06/23/1998
  • Est. Priority Date: 07/25/1994
  • Status: Expired due to Term
First Claim
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1. An ophthalmic aqueous preparation for use as artificial tear containing a viscosity thickener consisting of at least one hyaluronic acid salt, at a concentration of 0.05 to 2% by weight, as well as the following quantities of ionic species:

  • 40-95 mmol/l of sodium ions, 12-28 mmol/l of potassium ions, 0.4-1,5 mmol/l of calcium ions, 0.4-1.0 mmol/l of magnesium ions, 50-100 mmol/l of chloride ions, 7-20 mmol/l of phosphate ions, 0.7-2.5 mmol/l of citrate ions, and water,said composition having a viscosity versus shear rate, measured at 32°

    C. from 10.0 to 200.0 cps at a shear rate of 2 sec-1 and from 10 to 5 cps at a shear rate of 1000 sec-1, and an osmolarity from 140 to 280 mOsm/l.

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