Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
First Claim
1. A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
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Accused Products
Abstract
Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
128 Citations
16 Claims
- 1. A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
- 6. A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein selected from the group consisting of collagen, elastin, silk, and keratin, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
- 13. A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein, further comprising an intervening group of from 1 to 50 amino acids in length between at least 2 repeating units.
Specification