Method and apparatus for nuclear magnetic resonance imaging of physiological function information

• US 5,771,893 A
• Filed: 09/06/1995
• Issued: 06/30/1998
• Est. Priority Date: 09/06/1994
• Status: Expired due to Term

• Current Assignee: Kabushiki Kaisha Toshiba (Toshiba Corporation)
• Original Assignee: Kabushiki Kaisha Toshiba (Toshiba Corporation)
• Inventors: Kassai, Yoshimori, Kuhara, Shigehide, Kanayama, Shoichi, Calderon, Arturo
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/524,257
• Time in Patent Office: 1,028 Days
• Field of Search: 128/653.2, 128/653.3, 324/306, 324/307, 324/309
• US Class Current: 600/419
• CPC Class Codes: G01R 33/4806 Functional imaging of brain activation
• CPC Class Codes: G01R 33/5616 using gradient refocusing, e.g. EPI
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

A nuclear magnetic resonance imaging scheme suitable for an imaging of a physiological function information on a living body. The scheme uses a pulse sequence for realizing a first imaging scheme for obtaining the blood vessel image and a second imaging scheme for obtaining the physiological function image such as a brain function image by a single execution of the pulse sequence, where the first imaging scheme is executed before the second imaging scheme by controlling resolutions and imaging regions for the respective imaging schemes appropriately. The pulse sequence can also realize a third imaging scheme for obtaining the physical shape image, which is to be executed between the first imaging scheme and the second imaging scheme. The physiological function image can be obtained by selecting valid data from the image data acquired with/without stimulation or load by using the t-test, and determining active portions from the selected valid data by using the paired t-test. The physiological function image can then be displayed in superposition with the blood vessel image and/or the physical shape image.

Claims

1. A method for nuclear magnetic resonance imaging, comprising the steps of:

imaging a body to be examined placed in a homogeneous static magnetic field by applying radio frequency magnetic field and gradient fields having a slicing gradient field, a reading gradient field and a phase encoding gradient field, according to a pulse sequence in which a pulse of said radio frequency magnetic field and a pulse of said slicing gradient field are applied for selectively exciting the body to be examined in one slicing direction, a pulse of said reading gradient field for suppressing a motion artifact is applied during an application of a pulse of said phase encoding gradient field, and field echoes are sequentially generated by sequentially switching said reading gradient field, detecting nuclear magnetic resonance signals emitted from the body to be examined in response to the radio frequency magnetic field and the gradient magnetic fields, and processing the nuclear magnetic resonance signals to construct nuclear magnetic resonance images; and

controlling the pulse sequence by varying periods for switching said reading gradient field so as to realize a first imaging scheme for acquiring first image date emphasizing the nuclear magnetic resonance signals from blood flow portions in a desired region of the body to be examined, and a second imaging scheme for acquiring second image data emphasizing a change of a magnetic field inhomogeneity due to a change of an amount of blood flow in the desired region of the body to be examined, by a single execution of the pulse sequence at the imaging step.

2. The method of claim 1, wherein the controlling step controls the pulse sequence to execute the first imaging scheme before the second imaging scheme.

3. The method of claim 1, wherein the controlling step controls the pulse sequence such that the first image data are acquired at a high spatial resolution, while the second image data are acquired at a high time resolution.

4. The method of claim 1, wherein the controlling step also controls the pulse sequence such that at least one of a number of phase encoding steps, a number of slice encoding steps, and a number of slices is set up independently for the first and second imaging schemes.

5. The method of claim 1, wherein the controlling step also controls the pulse sequence such that an imaging region is set up independently for the first and second imaging schemes.

6. The method of claim 1, wherein the controlling step also controls the pulse sequence to realize a third imaging scheme for acquiring third image data indicating a physical shape information on the desired region of the body to be examined.

7. The method of claim 6, wherein the controlling step controls the pulse sequence to execute the third imaging scheme between the first imaging scheme and the second imaging scheme.

8. The method of claim 6, wherein the controlling step also controls the pulse sequence such that at least one of a number of phase encoding steps, a number of slice encoding steps, and a number of slices is set up independently for the first, second, and third imaging schemes.

9. The method of claim 6, wherein the controlling step also controls the pulse sequence such that an imaging region is set up independently for the first, second, and third imaging schemes.

10. The method of claim 6, further comprising the steps of:

repeating the imaging step and the controlling step under a first condition in which a physiological function at the desired region of the body to be examined is inactive and under a second condition in which a physiological function at the desired region of the body to be examined is active;

obtaining a physiological function image by applying subtraction/statistical processing on the second image data acquired by the second imaging scheme under the first and second conditions, while obtaining a blood vessel image from the first image data acquired by the first imaging scheme and a physical shape image from the third image data acquired by the third imaging scheme;

matching voxel sizes along reading, phase encoding, and slicing directions in the physiological function image, the blood vessel image, and the physical shape image obtained at the obtaining step; and

displaying at least two of the physiological function image, the blood vessel image, and the physical shape image in superposition, by using the voxel sizes matched at the matching step.

11. An apparatus for nuclear magnetic resonance imaging, comprising:

imaging means for imaging a body to be examined placed in a homogeneous static magnetic field by applying radio frequency magnetic field and gradient magnetic fields having a slicing gradient field, a reading gradient field and a phase encoding gradient field, according to a pulse sequence in which a pulse of said radio frequency magnetic field and a pulse of said slicing gradient field are applied for selectively exciting the body to be examined in one slicing direction, a pulse of said reading gradient field for suppressing a motion artifact is applied during an application of a pulse of said phase encoding gradient field, and field echoes are sequentially generated by sequentially switching said reading gradient field, detecting nuclear magnetic resonance signals emitted from the body to be examined in response to the radio frequency magnetic field and the gradient magnetic fields, and processing the nuclear magnetic resonance signals to construct nuclear magnetic resonance images; and

control means for controlling the pulse sequence by varying periods for switching said reading gradient field so as to realize a first imaging scheme for acquiring first image data emphasizing the nuclear magnetic resonance signals from blood flow portions in a desired region of the body to be examined, and a second imaging scheme for acquiring second image data emphasizing a change of a magnetic field inhomogeneity due to a change of an amount of blood flow in the desired region of the body to be examined, by a single execution of the pulse sequence at the imaging means.

12. The apparatus of claim 11, wherein the control means controls the pulse sequence to execute the first imaging scheme before the second imaging scheme.

13. The apparatus of claim 11, wherein the control means controls the pulse sequence such that the first image data are acquired at a high spatial resolution, while the second image data are acquired at a high time resolution.

14. The apparatus of claim 11, wherein the control means also controls the pulse sequence such that at least one of a number of phase encoding steps, a number of slice encoding steps, and a number of slices is set up independently for the first and second imaging schemes.

15. The apparatus of claim 11, wherein the control means also controls the pulse sequence such that an imaging region is set up independently for the first and second imaging schemes.

16. The apparatus of claim 11, wherein the control means also controls the pulse sequence to realize a third imaging scheme for acquiring third image data indicating a physical shape information on the desired region of the body to be examined.

17. The apparatus of claim 16, wherein the control means controls the pulse sequence to execute the third imaging scheme between the first imaging scheme and the second imaging scheme.

18. The apparatus of claim 16, wherein the control means also controls the pulse sequence such that at least one of a number of phase encoding steps, a number of slice encoding steps, and a number of slices is set up independently for the first, second, and third imaging schemes.

19. The apparatus of claim 16, wherein the control means also controls the pulse sequence such that an imaging region is set up independently for the first, second, and third imaging schemes.

20. The apparatus of claim 16, wherein the imaging means and the control means repeats an execution of the pulse sequence under a first condition in which a physiological function at the desired region of the body to be examined is inactive and under a second condition in which a physiological function at the desired region of the body to be examined is active, and the apparatus further comprises:

means for obtaining a physiological function image by applying subtraction/statistical processing on the second image data acquired by the second imaging scheme under the first and second conditions, while obtaining a blood vessel image from the first image data acquired by the first imaging scheme and a physical shape image from the third image data acquired by the third imaging scheme;

means for matching voxel sizes along reading, phase encoding, and slicing directions in the physiological function image, the blood vessel image, and the physical shape image obtained by the obtaining means; and

means for displaying at least two of the physiological function image, the blood vessel image, and the physical shape image in superposition, by using the voxel sizes matched by the matching means.