Analyzing apparatus using disposable reaction vessels

• US 5,772,962 A
• Filed: 05/28/1996
• Issued: 06/30/1998
• Est. Priority Date: 05/29/1995
• Status: Expired due to Term

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: Itoh, Kenichi, Sato, Takashi, Uchida, Hiroyasu
• Primary Examiner(s): Le, Long V.
• Application Number:
  US08/654,714
• Time in Patent Office: 763 Days
• Field of Search: 422/63, 422/64, 422/65, 422/67, 422/100, 422/104, 436/43, 436/47, 436/48, 436/49, 436/50, 436/54, 436/174, 436/180
• US Class Current: 422/67
• CPC Class Codes: B01L 9/543 for disposable pipette tips, e.g. racks or cassettes
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/103 using disposable tips
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/115831 Condition or time responsive

Abstract

Unused reaction vessels and unused nozzle tips are arranged in a matrix on a vessel magazine and a tip magazine, respectively. A carrying mechanism for moving a gripping mechanism along X- and Y-axes seizes unused nozzle tips on the tip magazine one by one in order, and transfers them to a tip attaching station. The carrying mechanism also seizes unused reaction vessels on the vessel magazine one by one in order starting from one end of the first row. A delivery mechanism, after having attached a nozzle tip on the tip attaching station to a nozzle holder, pours sample and reagent into a reaction vessel on a delivery station. The reaction vessel is carried by a gripping mechanism to an incubator where the mixture of sample and reagent is incubated. After incubation, the reaction vessel is transferred to a shipper station where the reaction solution is extracted by suction with a shipper nozzle which introduces the solution into the flow cell of a measuring device. Prior to the above analyzing operation, the gripping mechanism with its fingers kept closed moves about over the delivery station and the incubator to checking for any obstacles, and disposes of any as necessary.

Claims

1. An analyzing apparatus in which a sample and a reagent react in a reaction vessel to produce a reaction solution, the reaction solution is introduced into a measuring device, and the reaction vessel is discarded, said apparatus comprising:

gripping means capable of seizing a reaction vessel and transporting said reaction vessel to a delivery station;

carrying means for moving said gripping means along X- and Y-axes;

a delivery station;

delivery means for delivering the sample and reagent into said reaction vessel at said delivery station;

an incubator for incubating a mixture of the sample and the reagent in said reaction vessel;

a vessel magazine having a plurality of reaction vessels arranged thereupon; and

control means for controlling said carrying means in such a manner as to move said gripping means over said delivery station and over said incubator to check for presence of any obstacle thereon, before said gripping means transfers a reaction vessel from said vessel magazine to said delivery station;

wherein said delivery station, said incubator, and said vessel magazine are disposed in a movable area of said gripping means;

wherein said carrying means is equipped with a moving member having said gripping means, and said moving member is provided with a detecting means for detecting presence of an obstacle; and

wherein said gripping means is lowered with finger members kept closed from a position above said delivery station or above said incubator, when said gripping means checks for presence of an obstacle.

2. An analyzing apparatus according to claim 1,

wherein, if an obstacle is found on said delivery station or on said incubator as a result of checking for presence of an obstacle, said control means orders said gripping means to seize said obstacle, and then to move said obstacle to a waste position.

3. An analyzing apparatus in which a sample and a reagent react in a reaction vessel to produce a reaction solution, the reaction solution is introduced into a measuring device, and the reaction vessel is discarded, said apparatus comprising:

gripping means capable of seizing a reaction vessel and transporting said reaction vessel to a delivery station;

carrying means for moving said gripping means along X- and Y-axes;

a delivery station;

delivery means for delivering the sample and reagent into said reaction vessel at said delivery station;

an incubator for incubating a mixture of the sample and the reagent in said reaction vessel;

a vessel magazine having a plurality of reaction vessels arranged thereupon;

wherein said vessel magazine holds said reaction vessels in rows; and

control means for controlling said carrying means to carry said reaction vessels one by one starting from one end of a topmost row in said vessel magazine to said delivery station;

wherein said delivery station, said incubator, and said vessel magazine are disposed in a movable area of said gripping means; and

wherein said gripping means has two finger members of which one is smaller than the other, and of which, when said gripping means seizes a reaction vessel, one finger member is placed on a free, open space devoid of any reaction vessel and the other finger member is placed between adjacent reaction vessels.

4. An analyzing apparatus to claim 3,

wherein said carrying means is provided with a detecting means for detecting a reaction vessel, and said control means resets a sequence of how reaction vessels are carried when said detecting means detects a reaction vessel at one end of the topmost row in said vessel magazine.

5. An analyzing apparatus according to claim 3, further comprising a tip magazine containing rows of unused nozzle tips therein, and a tip attaching station for attaching unused nozzle tip to a nozzle holder of said delivery means.

6. An analyzing apparatus according to claim 5,

wherein a head of said reaction vessel has substantially the same external diameter as the head of said nozzle tip.

7. An analyzing apparatus according to claim 3,

wherein said delivery station has a capacity for plural reaction vessels thereupon, and said delivery means, after having delivered sample and diluting solution into a first reaction vessel at said delivery station, transfers by pipetting a part of a diluted sample thus formed in the first reaction vessel to a second reaction vessel at said delivery station.

8. An analyzing apparatus in which a sample and a reagent react in a reaction vessel to form a reaction solution, the reaction solution is measured in a measuring device, and the reaction vessel is thereafter discarded, said apparatus comprising:

a vessel magazine having a plurality of reaction vessels thereon;

a delivery station for receiving a sample and a reagent into a reaction vessel thereon;

gripping means having finger members for seizing and transferring a reaction vessel;

carrying means for moving said gripping means so as to carry one of said reaction vessels;

control means for controlling movement of said carrying means; and

detection means for detecting the existence of a reaction vessel by lowering said gripping means;

wherein said control means controls said carrying means so as to lower said gripping means to permit said detection means to detect a reaction vessel, to be transferred by said gripping means from one of said vessel magazine and said delivery station, from a position above said one of said vessel magazine and said delivery station, before said gripping means transfers said reaction vessel.

9. An analyzing apparatus according to claim 8,

wherein said control means comprises judging means for judging the existence of an obstacle by detecting the existence of a reaction vessel at said delivery station.

10. An analyzing apparatus according to claim 9,

wherein said carrying means is controlled so as to carry said obstacle from said delivery station to a waste position based on a judgment of said judging means.

11. An analyzing apparatus according to claim 8,

wherein said control means comprises recognizing means for recognizing that a vessel magazine is a new vessel magazine by detecting the existence of a reaction vessel at a specific end of a topmost row on said vessel magazine.

12. An analyzing apparatus in which a sample and a reagent react in a reaction vessel to produce a reaction solution, the reaction solution is measured in a measuring device, and the reaction vessel is thereafter discarded, said apparatus comprising:

a tip magazine for holding unused nozzle tips in plural rows, said tip magazine being set at a fixed position;

gripping means having finger members for seizing and transferring a nozzle tip;

a tip attaching station for attaching an unused nozzle tip to a nozzle holder of said delivery means;

carrying means for moving said gripping means so as to carry said unused nozzle tip from said tip magazine to said tip attaching station;

detection means for detecting the existence of a nozzle tip by lowering said gripping means; and

control means for controlling said carrying means so as to lower said gripping means to permit said detection means to detect a nozzle tip, to be transferred by said gripping means from one of said tip magazine and said tip attaching station, from a position above said one of said tip magazine and said tip attaching station, before said gripping means transfers said nozzle tip.

13. An analyzing apparatus according to claim 12,

wherein said control means comprises judging means for judging the existence of an obstacle by detecting the existence of a nozzle tip at said tip attaching station.

14. An analyzing apparatus according to claim 13,

wherein said carrying means is controlled so as to carry said obstacle from said tip attaching station to a waste position based on a judgment of said judging means.

15. An analyzing apparatus according to claim 12,

wherein said control means comprises recognizing means for recognizing that a tip magazine is a new tip magazine by detecting the existence of an unused tip nozzle at a specific end of a topmost row on said tip magazine.