Optical measuring method and an optical measuring apparatus for determining the internal structure of an object

• US 5,774,223 A
• Filed: 08/27/1996
• Issued: 06/30/1998
• Est. Priority Date: 08/28/1995
• Status: Expired due to Term

• Current Assignee: Hamamatsu Photonics KK
• Original Assignee: Hamamatsu Photonics KK
• Inventors: Yamashita, Yutaka, Tsuchiya, Yutaka, Miwa, Mitsuharu, Urakami, Tsuneyuki
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US08/703,766
• Time in Patent Office: 672 Days
• Field of Search: 356/394, 356/39, 356/41, 356/432, 356/442, 356/341, 356/5, 356/4, 356/40, 356/427, 356/121, 356/433, 356/337, 356/338, 364/480, 364/481, 364/486, 364/569, 364/579, 250/226, 250/339, 250/573, 250/574, 250/343, 250/564, 250/565
• US Class Current: 356/394
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence

Abstract

An optical measuring method and an optical measuring apparatus are capable of obtaining the true mean time delay of a light waveform within a short time for the purpose of obtaining information on the internal structure of an object. Calculations include a first mean time delay when the light path includes the object, a second mean time delay when the light path does not include the object, and a subtraction of the second mean time delay from the first mean time delay to obtain a true mean time delay.

Claims

1. An optical measuring method comprising:

a first step of, in a first state in which a measured object is placed in a predetermined place, emitting probe light from a light source onto said measured object and detecting said probe light transmitted or reflected by said measured object by means of light detecting means to obtain a first mean time delay of said probe light;

a second step of, in a second state in which said measured object is not placed in said predetermined place, emitting said probe light from said light source to said predetermined place and detecting said probe light passing through said predetermined place without intervention of said measured object by said light detecting means to obtain a second mean time delay; and

a third step of subtracting said second mean time delay from said first mean time delay to obtain a true mean time delay.

2. The method according to claim 1, further comprising a fourth step of analyzing said true mean time delay obtained in said third step to obtain internal information of said measured object.

3. The method according to claim 1, further comprising:

a fifth step of, in said first state in which said measured object is placed in said predetermined place, emitting said probe light from said light source to said measured object and detecting said probe light transmitted or reflected by said measured object by said light detecting means to obtain a first integral value of a waveform of said probe light;

a sixth step of, in said second state in which said measured object is not placed in said predetermined place, emitting said probe light from said light source to said predetermined place and detecting said probe light passing through said predetermined place without intervention of said measured object by said light detecting means to obtain a second integral value of a waveform of said probe light; and

a seventh step of obtaining a ratio of said first integral value and said second integral value.

4. The method according to claim 3, further comprising an eighth step of analyzing said true mean time delay obtained in said third step and the ratio of said first integral value and said second integral value obtained in said seventh step to obtain internal information of said measured object.

5. The method according to claim 1, wherein said measured object is a scattering medium and wherein said internal information is at least one information selected from the group consisting of a constant concerning absorption of said scattering medium, a constant concerning scattering thereof, a refractive index thereof, a degree of heterogeneity of composition thereof, and a constant concerning structure thereof.

6. An optical measuring apparatus comprising:

a light source for emitting probe light to be guided to a predetermined place;

light detecting means for detecting said probe light output from said predetermined place; and

a first arithmetic processing portion for calculating a first mean time delay of the probe light transmitted or reflected by a measured object, based on said probe light detected by said light detecting means in a first state in which said measured object is placed in said predetermined place, calculating a second mean time delay of the probe light passing through said predetermined place without intervention of said measured object, based on said probe light detected by said light detecting means in a second state in which said measured object is not placed in said predetermined place, and subtracting said second mean time delay from said first mean time delay to obtain a true mean time delay.

7. The apparatus according to claim 6, wherein said first arithmetic processing portion comprises a mean time delay arithmetic unit for calculating a mean time delay of said probe light detected by said light detecting means to obtain said first mean time delay and said second mean time delay, and a difference arithmetic unit for subtracting said second mean time delay from said first mean time delay to obtain the true mean time delay.

8. The apparatus according to claim 7, wherein said difference arithmetic unit comprises first switching means for switching a destination of output data from said mean time delay arithmetic unit, first memory means connected to said first switching means and arranged to memorize said second mean time delay, said difference arithmetic means connected to said first switching means and to said first memory means and arranged to subtract said second mean time delay stored in said first memory means from said first mean time delay to obtain said true mean time delay.

9. The apparatus according to claim 6, further comprising first light waveguide means, one end of which is connected to said light source and the other end of which is disposed to face said predetermined place, for guiding said probe light to said predetermined place, and second light waveguide means, one end of which is connected to said light detecting means and the other end of which is disposed to face said predetermined place, for guiding said probe light output from said predetermined place to said light detecting means.

10. The apparatus according to claim 6, further comprising an analyzing unit for analyzing said true mean time delay obtained by said first arithmetic processing portion to obtain the internal information of said measured object.

11. The apparatus according to claim 10, wherein said measured object is a scattering medium and wherein said analyzing unit is arranged to execute an analysis to obtain a constant concerning absorption of said scattering medium, based on said true mean time delay obtained by said first arithmetic processing portion.

12. The apparatus according to claim 10, wherein said measured object is a scattering medium and wherein said analyzing unit is arranged to execute an analysis to obtain a constant concerning scattering of said scattering medium, based on said true mean time delay obtained by said first arithmetic processing portion.

13. The apparatus according to claim 10, wherein said measured object is a scattering medium and wherein said analyzing unit is arranged to execute an analysis to obtain a refractive index of said scattering medium, based on said true mean time delay obtained by said first arithmetic processing portion.

14. The apparatus according to claim 10, wherein said measured object is a scattering medium and wherein said analyzing unit is arranged to execute an analysis to obtain a degree of heterogeneity of composition of said scattering medium, based on said true mean time delay obtained by said first arithmetic processing portion.

15. The apparatus according to claim 10, wherein said measured object is a scattering medium and wherein said analyzing unit is arranged to execute an analysis to obtain a constant concerning structure of said scattering medium, based on said true mean time delay obtained by said first arithmetic processing portion.

16. The apparatus according to claim 10, further comprising a second arithmetic processing portion for calculating a first integral value of a waveform of said probe light transmitted or reflected by said measured object, based on the probe light detected by said light detecting means in the first state in which said measured object is placed in said predetermined place, calculating a second integral value of a waveform of said probe light passing through said predetermined place without intervention of said measured object, based on said probe light detected by said light detecting means in the second state in which said measured object is not placed in said predetermined place, and obtaining a ratio of said first integral value and said second integral value,

wherein said analyzing unit is arranged to analyze said true mean time delay obtained by said first arithmetic processing portion and the ratio of said first integral value and said second integral value obtained by said second arithmetic processing portion to obtain the internal information of said measured object.

17. The apparatus according to claim 16, wherein said second arithmetic processing portion comprises an integration arithmetic unit for calculating an integral value of a waveform of said probe light detected by said light detecting means to obtain said first integral value and said second integral value, and a ratio arithmetic unit for obtaining the ratio of said first integral value and said second integral value.

18. The apparatus according to claim 17, wherein said ratio arithmetic unit comprises second switching means for switching a destination of output data from said integration arithmetic unit, second memory means connected to said second switching means and arranged to store said second integral value, and ratio arithmetic means connected to said second switching means and to said second memory means and arranged to obtain the ratio of said first integral value and said second integral value stored in said second memory means.