Heated perfusion balloon for reduction of restenosis

• US 5,775,338 A
• Filed: 01/10/1997
• Issued: 07/07/1998
• Est. Priority Date: 01/10/1997
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Hastings, Roger N.
• Primary Examiner(s): Millin, Vincent
• Assistant Examiner(s): CAMPEN, KELLY SCAGGS
• Application Number:
  US08/781,663
• Time in Patent Office: 543 Days
• Field of Search: 128/898, 606/7, 606/27-31, 606/113, 607/101, 607/98, 607/104, 607/122, 607/6, 607/96, 607/50, 607/62, 604/113, 604/915
• US Class Current: 128/898
• CPC Class Codes: A61B 18/00 Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body eye surgery A61F9/007; ear surgery A61F11/00
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element

Abstract

A method for inhibiting the restenosis of blood vessel walls after angioplasty, including the application of low grade heat to the vessel walls. A heat applying perfusion catheter is advanced to a recently dilatated vessel region. Heat is applied to the region walls to inhibit restenosis. A preferred temperature range is from 42 to 45 degrees C. A preferred time period for treatment is from 3 to 6 minutes. A perfusion catheter allows longer heat treatment times. Electrical resistance heat, radio frequency current passage through inflation fluid, and microwave radiation are all heat sources within the scope of the invention.

Claims

1. A method for inhibiting restenosis in a vessel region comprising the steps of:

heating said vessel region at a temperature in the range of about 40 degrees C. to about 45 degrees C. for a time period of 10 seconds to 60 minutes.

2. A method for inhibiting restonosis as recited in claim 1, wherein said temperature is within the range of about 42 degrees to about 45 degrees C.

3. A method for inhibiting restonosis as recited in claim 1, wherein said time period is within the range from about 30 seconds to about 10 minutes.

4. A method for inhibiting restonosis as recited in claim 1, wherein said time period is within the range from about 10 minutes to about 60 minutes.

5. A method as recited in claim 1, wherein said heating is produced using a heat source selected from the group consisting of electric resistance, radio-frequency current passage through fluid, and microwave radiation.

6. A method as recited in claim 1, further comprising the step of measuring blood temperature within the vessel and measuring the vessel wall temperature.