Intravasoular stent and method
First Claim
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1. A device for delivery of a drug into a body lumen comprising:
- (a) a catheter;
(b) a generally cylindrical, radially expandable stent body on the catheter; and
(c) a porous coating on the stent body comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer such that the polymer has a first concentration of therapeutic substance on a portion of the coating nearest to the stent body and a second, lesser concentration of therapeutic substance on a portion of the coating away from the stent body.
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Abstract
A device for delivery of a therapeutic substance into a body lumen including a polymer in intimate contact with a drug on a stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer.
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Citations
12 Claims
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1. A device for delivery of a drug into a body lumen comprising:
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(a) a catheter; (b) a generally cylindrical, radially expandable stent body on the catheter; and (c) a porous coating on the stent body comprising a polymer and a therapeutic substance in a solid/solid solution with the polymer such that the polymer has a first concentration of therapeutic substance on a portion of the coating nearest to the stent body and a second, lesser concentration of therapeutic substance on a portion of the coating away from the stent body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification