Medicinal aerosol formulations
First Claim
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1. A method of making an aerosol formulation suitable for delivery to the lung by inhalation comprising the steps of:
- (a) providing an aerosol container, and(b) charging to said container;
(i) a medicament in an amount sufficient to provide a plurality of therapeutically effective doses,(ii) an amount of propellant sufficient to propel from said container said plurality of therapeutically effective doses, said propellant being substantially free of chlorofluorocarbons and comprising 1,1,1,2-tetrafluoroethane; and
(iii) at least one compound selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, isopropyl myristate, and mixtures thereof, and(iv) a surface active agent.
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Abstract
A self-propelling aerosol formulation which may be free from CFC'"'"'s which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
134 Citations
1 Claim
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1. A method of making an aerosol formulation suitable for delivery to the lung by inhalation comprising the steps of:
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(a) providing an aerosol container, and (b) charging to said container; (i) a medicament in an amount sufficient to provide a plurality of therapeutically effective doses, (ii) an amount of propellant sufficient to propel from said container said plurality of therapeutically effective doses, said propellant being substantially free of chlorofluorocarbons and comprising 1,1,1,2-tetrafluoroethane; and (iii) at least one compound selected from the group consisting of ethyl alcohol, isopropyl alcohol, n-pentane, isopentane, neopentane, isopropyl myristate, and mixtures thereof, and (iv) a surface active agent.
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Specification
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Current Assignee3M Innovative Properties Company (3M Company)
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Original AssigneeRiker Laboratories, Inc. (3M Company)
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InventorsGreenleaf, David J., Purewal, Tarlochan S.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)Benston, Jr., William E.
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Application NumberUS08/784,436Time in Patent Office537 DaysField of Search424/45, 424/46, 252/305US Class Current424/45CPC Class CodesA61K 9/008 comprising drug dissolved o...A61K 9/124 characterised by the propel...
