Neurospora hosts for the production of recombinant proteins, and methods for producing same
First Claim
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1. A mutant Neurospora strain produced from a parent Neurospora strain, wherein said mutant Neurospora strain is selected to produce from about 27 to 125 times the amount of recombinant protein as that produced by the parent strain.
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Abstract
The present invention provides improved host cells for use in producing secreted recombinant proteins, methods of making the improved hosts and uses thereof. The invention specifically provides strains of Neurospora crassa which produce reduced levels of extracellular proteases when compared with wild-type Neurospora crassa.
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2 Claims
- 1. A mutant Neurospora strain produced from a parent Neurospora strain, wherein said mutant Neurospora strain is selected to produce from about 27 to 125 times the amount of recombinant protein as that produced by the parent strain.
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Current AssigneeUniversity of Hawai'i
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Original AssigneeUniversity of Hawai'i
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InventorsStuart, W. Dorsey
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Primary Examiner(s)Kemmerer, Elizabeth C.
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Assistant Examiner(s)Lathrop, Brian
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Application NumberUS08/573,020Time in Patent Office935 DaysField of Search435/254.4, 435/256.8, 435/69.1US Class Current435/69.1CPC Class CodesC12N 1/145 Fungal isolatesC12N 15/80 for fungiC12R 2001/645 Fungi ; Processes using fungi
