Therapeutic diet for metabolic abnormalities found in animals with lymphoma

• US 5,776,913 A
• Filed: 10/10/1995
• Issued: 07/07/1998
• Est. Priority Date: 10/10/1995
• Status: Expired due to Term

• Current Assignee: Colorado State University Research Foundation
• Original Assignee: Colgate-Palmolive Company
• Inventors: Gross, Kathy L., Hand, Michael S., Davenport, Deborah J., Ogilvie, Gregory K.
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US08/544,421
• Time in Patent Office: 1,001 Days
• Field of Search: 514/558, 514/560, 514/524, 514/57, 514/78, 514/77
• US Class Current: 514/57
• CPC Class Codes: A23K 20/142 Amino acids; Derivatives thereof
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23K 50/48 Moist feed
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

The severity of metabolic disturbance in animals with cancer is mitigated by feeding the animal a nutritionally balanced food composition having a fat content of about 27 to 35%, on a dry matter basis, a carbohydrate content of about 15 to about 27% on a dry matter basis in which is present a mixture of arginine, omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, the weight ratio of omega-3, omega-6 fatty acid being in the range of 0.3:1 to 3.5:1.

Claims

1. A method for mitigating the severity of metabolic disturbances in animals with cancer cachexia associated with lymphoma comprising (a) forming a nutritionally balanced petfood composition having a fat content of about 27 to 35% on a dry matter basis, a carbohydrate content of about 15 to about 27% on a dry matter basis in which is also present a mixture of arginine, omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, and (b) feeding the composition to the animal with cancer.

2. The method of claim 1 wherein arginine is present in the food composition at a concentration of about 2.0 to about 3.5% on a dry matter basis.

3. The method of claim 1 wherein the omega-3 polyunsaturated fatty acid is present in the food composition at a concentration of about 2.5 to about 7.5% on a dry matter basis.

4. The method of claim 1 wherein the omega-6 polyunsaturated acid is present in the food composition at a concentration of about 2.0 about 6.0% on a dry matter basis.

5. The method of claim 1 wherein the weight ratio of omega-3 polyunsaturated fatty acid to omega-6 fatty acids is about 0.3:

1-3.5;

1.

6. A therapeutic composition for mitigating the severity of metabolic disturbance in animals with cancer cachexia associated with lymphoma comprising (a) a nutritionally balanced food having a fat content of about 27 to 35% on a dry matter basis, a carbohydrate content of about 15 to about 27% on a dry matter basis in which is present a mixture of arginine, omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, the weight ratio of omega-3 to omega-6 fatty acid being in the range of about 0.3:

1 to 3.5;

1.

7. The composition of claim 6 wherein arginine is present in the food composition at a concentration of about 2.0 to about 3.5% on a dry matter basis.

8. The composition of claim 6 wherein the omega-3 polyunsaturated fatty acid is present in the food composition at a concentration of about 2.5 to about 7.5% by on a dry matter basis.

9. The composition of claim 6 wherein the omega-6 polyunsaturated acid is present in the food composition at a concentration of about 2.0 to about 6.0% by on a dry matter basis.