Method of treating dysfunctional bladder syndromes by electromotive drug administration
First Claim
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1. A method of treating dysfunctional bladder syndromes by Electromotive Drug Administration of intravesically instilled drug into a bladder wall, said method comprising the steps of:
- a) inserting a catheter via a urethra into a bladder and draining said bladder of urinary contents,b) administering into said bladder via said catheter an electrically conductive aqueous solution comprising at least a local anaesthetic agent and an antimuscarinic agent to achieve both analgesia and relaxation of the detrusor muscle,c) inserting into said catheter a tubular anodic electrode connected to an external controllable power source, so that the internal tip of said electrode resides within that section of said catheter which is within the bladder cavity,d) placing in contact with an adapted skin location a cathodic electrode also connected to said external power source,e) supplying an electrical current from said power source to said electrodes,f) instituting a progressive active hydraulic dilatation of said bladder by infusing, portionwise, through said catheter, a solution to substantially achieve its maximum intravesical volume.
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Abstract
An intravesical method of treating dysfunctional bladder syndromes by Electromotive Drug Administration (EMDA) of local anaesthetic drugs, anti muscarinic drugs and sympathomimetic agents. The administration of said drugs combined with hydraulic bladder dilatation causes relaxation of the detrusor muscle, reversing the hypertonicity associated with dysfunctional bladder syndromes.
78 Citations
15 Claims
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1. A method of treating dysfunctional bladder syndromes by Electromotive Drug Administration of intravesically instilled drug into a bladder wall, said method comprising the steps of:
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a) inserting a catheter via a urethra into a bladder and draining said bladder of urinary contents, b) administering into said bladder via said catheter an electrically conductive aqueous solution comprising at least a local anaesthetic agent and an antimuscarinic agent to achieve both analgesia and relaxation of the detrusor muscle, c) inserting into said catheter a tubular anodic electrode connected to an external controllable power source, so that the internal tip of said electrode resides within that section of said catheter which is within the bladder cavity, d) placing in contact with an adapted skin location a cathodic electrode also connected to said external power source, e) supplying an electrical current from said power source to said electrodes, f) instituting a progressive active hydraulic dilatation of said bladder by infusing, portionwise, through said catheter, a solution to substantially achieve its maximum intravesical volume. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of treating dysfunctional bladder syndromes by Electromotive Drug Administration of intravesically instilled drug into a bladder wall, said method comprising the steps of:
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a) inserting a catheter via a urethra into a bladder and draining said bladder of urinary contents, b) administering into said bladder via said catheter an electrically conductive aqueous solution of at least one drug which causes relaxation of the detrusor muscle, c) inserting into said catheter a tubular anodic electrode connected to an external controllable power source, so that the internal tip of said electrode resides within that section of said catheter which is within the bladder cavity, d) placing in contact with an adapted skin location a cathodic electrode also connected to said external power source, e) supplying an electrical current from said power source to said electrodes, f) instituting a passive hydraulic dilatation of said bladder by clamping said catheter and thereby trapping inflowing urine within the bladder cavity and distending said bladder to substantially achieve its maximum intravesical volume. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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Specification