Devices and methods for application of intraluminal photopolymerized gels
First Claim
Patent Images
1. A device for delivery of a therapeutic agent to a body cavity or lumen, comprising:
- one or more elongated shafts, each with a proximal end, and a distal portion adapted for insertion into a body lumen or cavity;
at least one occlusion element mounted on one or more of the shafts;
at least one injection lumen in at least one shaft, suitable for injection of an agent into a treatment space defined at least at one end by the occlusion element, wherein said injection lumen communicates with at least one injection port located on the shaft; and
a flushing sleeve mounted about the injection port, and arranged on the shaft so as to create at least one axially-directed flushing port.
4 Assignments
0 Petitions
Accused Products
Abstract
Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.
-
Citations
72 Claims
-
1. A device for delivery of a therapeutic agent to a body cavity or lumen, comprising:
-
one or more elongated shafts, each with a proximal end, and a distal portion adapted for insertion into a body lumen or cavity; at least one occlusion element mounted on one or more of the shafts; at least one injection lumen in at least one shaft, suitable for injection of an agent into a treatment space defined at least at one end by the occlusion element, wherein said injection lumen communicates with at least one injection port located on the shaft; and a flushing sleeve mounted about the injection port, and arranged on the shaft so as to create at least one axially-directed flushing port. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
-
-
24. A device for delivery of a fluid to a body cavity or lumen, comprising:
-
an elongated shaft having a proximal end, and a distal portion adapted for insertion into a body lumen or cavity; and a flushing sleeve mounted about an injection port on the shaft, and arranged on the shaft so as to direct at least a portion of agent ejected from the injection port axially. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
-
-
32. Apparatus for treatment of a hollow organ or tissue lumen of a mammal comprising:
-
an elongated shaft having a distal portion adapted to be inserted into a hollow organ or tissue lumen of a mammal during treatment and a proximal portion adapted to remain outside the mammal during treatment; a first occlusion element at the distal portion of the shaft adapted to occlude the hollow organ or lumen and thereby, during the treatment of the organ or lumen, to prevent fluid flow therepast while fluid pressure in the lumen or organ does not exceed a threshold value; and a second occlusion element at the distal region of the shaft having an essentially circular cross section when expanded, spaced from the first occlusion element, adapted to occlude the hollow organ or tissue lumen and prevent fluid flow therepast, and being constructed and arranged to withstand during treatment a second fluid pressure, less than the threshold pressure, applied within the hollow organ or tissue lumen between the first and second occlusion elements thereby preventing fluid flow therepast and to allow fluid flow therepast during treatment at the threshold fluid pressure. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
-
-
45. A method of applying a fluid to the interior surface of a body lumen or cavity, comprising:
-
entering the lumen or cavity with a catheter having an elongated shaft that includes a distal end insertable into the lumen or cavity and a proximal end adapted to remain outside of the lumen or cavity; occluding the lumen or cavity with an occlusion element near the distal end of the shaft; and directing fluid toward the occlusion element so as to flush a region at an interface of the occlusion element and the surface of the lumen or cavity. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53)
-
-
54. A method of applying a fluid from an applicator to an interior surface of a body lumen or cavity having an axis of elongation, comprising:
directing fluid in a first, radial direction from the applicator towards the surface of the body lumen or cavity and simultaneously directing fluid from the applicator within the body lumen or cavity in a second, axial direction perpendicular to the first direction. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62, 63)
-
64. A method of applying a fluid to the interior surface of a body lumen or cavity, comprising:
-
occluding a diseased region of a hollow organ or tissue lumen of a mammal by positioning a first occlusion element in the hollow organ or lumen and positioning a second occlusion element, spaced from the first occlusion element, in the hollow organ or lumen, thereby defining a treatment space including the diseased region isolated by the occlusion elements; applying fluid to the occluded region; increasing pressure of the fluid; and allowing the pressurized fluid to escape from the occluded region past the second occlusion element, while preventing the fluid from escaping past the first occlusion element. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72)
-
Specification